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Gain-switched 311-nm Ti:Sapphire laser might be a potential treatment modality for atopic dermatitis

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Abstract

Phototherapy with 311-nm narrowband-UVB (NBUVB) is an effective adjuvant treatment modality for atopic dermatitis (AD). In this study, we evaluated the therapeutic effect of the newly developed gain-switched 311-nm Ti:Sapphire laser device using a NC/Nga mouse AD model. A total number of 50 mice were used in this study. Atopic dermatitis (AD) was induced in mice by exposure to Dermatophagoides farina. These, NC/Nga mice were then treated with conventional 311-nm NBUVB or the newly developed gain-switched 311-nm Ti:Sapphire laser. The clinical features, dermatitis severity scores, and scratching behavior were assessed. In addition, serologic analyses including inflammatory cytokines and histological analyses were performed. Gain-switched 311-nm Ti:Sapphire laser improved the AD-like skin lesions, severity, and symptoms of AD in the NC/Nga mouse model. This new laser also modulated the immune response found in the AD model, including hyper-IgE, upregulated Th2 cytokines, and the Th2-mediated allergic inflammatory reaction. Gain-switched 311-nm Ti:Sapphire laser shows therapeutic promise via an immune-modulation mechanism in an AD mouse model. These data suggest that gain-switched 311-nm Ti:Sapphire laser may be useful as a targeted phototherapy modality for AD.

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    Authors and Affiliations

    1. Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea

      Sun Young Choi, Chang Taek OH, Tae-Rin Kwon, Hyun Jung Kwon, Eun Ja Choi, Yu-Jin Jang, Myeung Nam Kim & Beom Joon Kim

    2. Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

      Sun Young Choi & Beom Joon Kim

    3. Department of Medicine, Graduate School, Chung-Ang University, Seoul, Korea

      Yu-Jin Jang

    4. Laseroptek, #204, 31, Galmachi-ro 24, Jungwon, Seongnam, Kyunggi, Korea

      Hye Sung Kim & Hong Chu

    5. Department of Otorhinolaryngology-Head and Neck Surgery, Chung-Ang University College of Medicine, Seoul, Korea

      Seog Kyun Mun

    6. Department of Dermatology, Chung Ang University Hospital, 224-1 Heukseok-dong, Dongjak-ku, Seoul, 156-755, South Korea

      Beom Joon Kim

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    1. Sun Young Choi
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    2. Chang Taek OH
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    Correspondence to Beom Joon Kim.

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    Sun Young Choi and Chang Taek OH contributed equally to this work.

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    Choi, S.Y., OH, C.T., Kwon, TR. et al. Gain-switched 311-nm Ti:Sapphire laser might be a potential treatment modality for atopic dermatitis. Lasers Med Sci 31, 1437–1445 (2016). https://doi.org/10.1007/s10103-016-2006-8

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    • DOI: https://doi.org/10.1007/s10103-016-2006-8

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