Skip to main content

Advertisement

Log in

Efficacy of adjunctive laser in non-surgical periodontal treatment: a systematic review and meta-analysis

  • Review Article
  • Published:
Lasers in Medical Science Aims and scope Submit manuscript

Abstract

To evaluate the efficacy of the adjunctive laser therapy in conventional non-surgical treatment of chronic periodontitis, an electronic search was performed through the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, MEDLINE, EMBASE, Scopus, Web of Science, China National Knowledge Infrastructure (CNKI), and China Biology Medicine (CBM) Disc, for relevant randomized controlled trials (RCTs) or quasi-RCTs. All the 12 included studies (11 RCTs and 1 quasi-RCT) were qualified for descriptive and quantitative analysis. Outcomes were divided into two groups according to the length of follow-ups (long term and short term). Subgroup analyses were performed based on the mode of laser (inside and outside mode). Among all included researches, reduction in probing depth (PD) and gain in clinical attachment level (CAL) were presented with the mean value and 95 % confidence interval, while bleeding on probing (BOP) was assessed descriptively. Meta-analysis suggested that adjunctive laser therapy reduced PD at 3 months [mean difference (MD) = −0.26, 95 % confidence interval (CI) range = −0.43 to −0.09, p = 0.003] but did not demonstrate significant effect on the CAL at either 3 months (MD = −0.03, 95 % CI range = −0.25 to 0.19, p = 0.79) or 6 months (MD = −0.11, 95 % CI range = −0.38 to 0.16, p = 0.43). Subgroup analyses indicated that laser therapy would be more effective when the probes were set up outside the periodontal pockets.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  1. Flemmig TF (1999) Periodontitis. In 1999 International workshop for a classification of periodontal diseases and conditions. Oak Brook, Illinois; October 30-November 2. Ann Periodontol 4(1):1–112

    Article  Google Scholar 

  2. O’Leary TJ (1986) The impact of research on scaling and root planing. J Periodontol 57(2):69–75

    Article  PubMed  Google Scholar 

  3. Kepic TJ, O’Leary TJ, Kafrawy AH (1990) Total calculus removal: an attainable objective? J Periodontol 61(1):16–20

    Article  PubMed  CAS  Google Scholar 

  4. Adriaens PA, Edwards CA, De Boever IA et al (1988) Ultrastructural observations on bacterial invasion in cementum and radicular dentin of periodontally diseased human teeth. J Periodontol 59:493–503

    Article  PubMed  CAS  Google Scholar 

  5. Aukhil I (2000) Biology of wound healing. Periodontol 22:44–50

    Article  CAS  Google Scholar 

  6. Bower RC (1979) Furcation morphology relative to periodontal treatment. Furcation root surface anatomy. J Periodontol 50:366–374

    Article  PubMed  CAS  Google Scholar 

  7. Cobb CM (1996) Non-surgical pocket therapy: mechanical. Ann Periodontol 1:443–490

    Article  PubMed  CAS  Google Scholar 

  8. Drisko CH (1996) Non-surgical pocket therapy: pharmacotherapeutics. Ann Periodontol 1:491–566

    Article  PubMed  CAS  Google Scholar 

  9. Brown MR, Gilbert P (1993) Sensitivity of biofilms to antimicrobial agents. J Appl Bacteriol 74(Suppl):87S–97S

    Article  PubMed  Google Scholar 

  10. Cobb CM (2006) Lasers in periodontics: a review of the literature. J Periodontol 77(4):545–564

    Article  PubMed  CAS  Google Scholar 

  11. Sanz I, Alonso B, Carasol M (2012) Nonsurgical treatment of periodontitis. J Evid Based Dent Pract S1:76–86

    Article  Google Scholar 

  12. Karlsson MR, Diogo Löfgren CI, Jansson HM (2008) The effect of laser therapy as an adjunct to non-surgical periodontal treatment in subjects with chronic periodontitis: a systematic review. J Periodontol 79:2021–2028

    Article  PubMed  Google Scholar 

  13. Schwarz F, Aoki A, Becker J et al (2008) Laser application in non-surgical periodontal therapy: a systematic review. J Clin Periodontol 35:29–44

    Article  PubMed  Google Scholar 

  14. Higgins JPT, Green S (2009) Cochrane handbook for systematic reviews of interventions. Wiley, Chichester

    Google Scholar 

  15. Pejcic A, Mirkovic D (2011) Anti-inflammatory effect of low level laser treatment on chronic periodontitis. Med Laser Appl 26:27–34

    Article  Google Scholar 

  16. Makhlouf M, Dahaba MM, Tuner J et al. (2012) Effect of adjunctive low level laser therapy (LLLT) on nonsurgical treatment of chronic periodontitis. Photomed Laser Surge 160–166. doi: 10.1089/pho.2011.3069

  17. SHI ZC, JIANG CM et al (2014) Effects of diode laser on the treatment for moderate to severe chronic periodontitis. Stomatology 34(4):245–248

    Google Scholar 

  18. Kreisler M, Al Haj H, d’Hoedt B (2005) Clinical efficacy of semiconductor laser application as an adjunct to conventional scaling and root planing. Lasers Surg Med 37:350–355

    Article  PubMed  Google Scholar 

  19. Aykol G, Baser U, Maden I et al (2011) The effect of low-level laser therapy as an adjunct to non-surgical periodontal treatment. J Periodontol 82:481–488

    Article  PubMed  Google Scholar 

  20. Lai SM, Zee KY, Lai MK et al (2009) Clinical and radiographic investigation of the adjunctive effects of a low-power He-Ne laser in the treatment of moderate to advanced periodontal disease: a pilot study. Photomed Laser Surg 27(2):287–293

    Article  PubMed  CAS  Google Scholar 

  21. Yılmaz S, Algan S, Gursoy H et al (2013) Evaluation of the clinical and antimicrobial effects of the Er:YAG laser or topical gaseous ozone as adjuncts to initial periodontal therapy. Photomed Laser Surg 31(6):293–298

    Article  PubMed  Google Scholar 

  22. Yilmaz S, Kut B, Gursoy H et al. (2012) Er:YAG laser versus systemic metronidazole as an adjunct to nonsurgical periodontal therapy: a clinical and microbiological study. Photomed Laser Surg 325–330

  23. Lopes BM, Melo RF, Thompson GM et al (2010) Clinical and microbiologic follow-up evaluations after non-surgical periodontal treatment with erbium:YAG laser and scaling and root planing. J Periodontol 81:682–691. doi:10.1902/jop.2014.140258

    Article  PubMed  Google Scholar 

  24. Kelbauskiene S, Baseviciene N, Goharkhay K et al (2011) One-year clinical results of Er,Cr:YSGG laser application in addition to scaling and root planing in patients with early to moderate periodontitis. Lasers Med Sci 26:445–452. doi:10.1007/s10103-010-0799-4

    Article  PubMed  Google Scholar 

  25. Ambrosini P, Miller N, Briancon S et al (2005) Clinical and microbiological evaluation of the effectiveness of the Nd:Yap laser for the initial treatment of adult periodontitis. A randomized controlled study. J Clin Periodontol 32:670–676. doi:10.1111/j.1600-051X.2005.00738.x

    Article  PubMed  Google Scholar 

  26. Rotundo R, Nieri M, Cairo F et al (2010) Lack of adjunctive benefit of Er:YAG laser in non-surgical periodontal treatment: a randomized split-mouth clinical trial. J Clin Periodontol 37:526–533. doi:10.1111/j.1600-051X.2010.01560.x

    Article  PubMed  Google Scholar 

  27. Huth KC, Neuhaus KW, Gygax M et al (2008) Clinical performance of a new laser fluorescence device for detection of occlusal caries lesions in permanent molars. J Dent 36(12):1033–1040

    Article  PubMed  CAS  Google Scholar 

  28. Zand N, Ataie-Fashtami L, Djavid GE et al (2009) Relieving pain in minor aphthous stomatitis by a single session of non-thermal carbon dioxide laser irradiation. Lasers Med Sci 24(4):515–520

    Article  PubMed  Google Scholar 

  29. Ge MK, He WL, Chen J et al (2014) Efficacy of low-level laser therapy for accelerating tooth movement during orthodontic treatment: a systematic review and meta-analysis. Lasers Med Sci. doi:10.1007/s10103-014-1538-z

    Google Scholar 

  30. Gómez C, Domínguez A, García-Kass AI et al (2011) Adjunctive Nd:YAG laser application in chronic periodontitis: clinical, immunological, and microbiological aspects. Lasers Med Sci 26:453–463. doi:10.1007/s10103-010-0795-8

    Article  PubMed  Google Scholar 

  31. Romeo U, Palaia G, Botti R et al (2010) Non-surgical periodontal therapy assisted by potassium–titanyl–phosphate laser: a pilot study. Lasers Med Sci 25:891–899. doi:10.1007/s10103-009-0738-4

    Article  PubMed  Google Scholar 

  32. Qadri T, Miranda L, Tunér J et al (2005) The short-term effects of low-level lasers as adjunct therapy in the treatment of periodontal inflammation. J Clin Periodontol 32:714–719. doi:10.1111/j.1600-051X.2005.00749.x

    Article  PubMed  CAS  Google Scholar 

  33. Ribeiro IW, Sbrana MC, Esper LA et al. (2008) Evaluation of the effect of the GaAlAs laser on subgingival scaling and root planing. Photomed Laser Surg 387–391. doi: 10.1089/pho.2007.2152

  34. Zingale J, Harpenau L, Chambers D et al (2012) Effectiveness of root planing with diode laser curettage for the treatment of periodontitis. J Calif Dent Assoc 40(10):786–793

    PubMed  Google Scholar 

  35. Calderín S, García-Núñez JA, Gómez C (2013) Short-term clinical and osteoimmunological effects of scaling and root planing complemented by simple or repeated laser phototherapy in chronic periodontitis. Lasers Med Sci 28:157–166. doi:10.1007/s10103-012-1104-5

    Article  PubMed  Google Scholar 

  36. Euzebio Alves VT, de Andrade AK, Toaliar JM et al (2013) Clinical and microbiological evaluation of high intensity diode laser adjutant to non-surgical periodontal treatment: a 6-month clinical trial. Clin Oral Investig 17:87–95. doi:10.1007/s00784-012-0703-7

    Article  PubMed  Google Scholar 

  37. Dukic W, Bago I, Aurer A et al (2013) Clinical effectiveness of diode laser therapy as an adjunct to non-surgical periodontal treatment: a randomized clinical study. J Periodontol 84:1111–1117. doi:10.1902/jop.2012.110708

    Article  PubMed  Google Scholar 

  38. Marques MM, Pereira AN, Fujihara NA et al (2004) Effect of low-power laser irradiation on protein synthesis and ultrastructure of human gingival fibroblasts. Lasers Surg Med 2004(34):260–265

    Article  Google Scholar 

  39. Silveira PC, Streck EL, Pinho RA (2007) Evaluation of mitochondrial respiratory chain activity in wound healing by low-level laser therapy. J Photochem Photobiol B 86:279–282

    Article  PubMed  CAS  Google Scholar 

  40. Alexandratou E, Yova D, Handris P et al (2002) Human fibroblast alterations induced by low power laser irradiation at the single cell level using confocal microscopy. Photochem Photobiol Sci 1:547–552

    Article  PubMed  CAS  Google Scholar 

  41. Hawkins D, Abrahamse H (2006) Effect of multiple exposures of low-level laser therapy on the cellular responses of wounded human skin fibroblasts. Photomed Laser Surg 24:705–714. doi:10.1089/pho.2006.24.705

    Article  PubMed  CAS  Google Scholar 

  42. Pereira AN, Eduardo CP, Matson E, Marques MM (2002) Effect of low-power laser irradiation on cell growth and procollagen synthesis of cultured fibroblasts. Lasers Surg Med 31:263–267

    Article  PubMed  Google Scholar 

  43. Moritz A, Schoop U, Goharkhay K et al (1998) Treatment of periodontal pockets with a diode laser. Lasers Surg Med 22:302–311

    Article  PubMed  CAS  Google Scholar 

  44. do Nascimento RX, Callera F (2006) Low-level laser therapy at different energy densities (0.1–2.0 J/cm2) and its effects on the capacity of human long-term cryopreserved peripheral blood progenitor cells for the growth of colony-forming units. Photomed Laser Surg 24(5):601–604

    Article  PubMed  Google Scholar 

  45. Goulart CS, Nouer PR, Mouramartins L et al (2006) Photoradiation and orthodontic movement: experimental study with canines. Photomed Laser Surg 24(2):192–196

    Article  PubMed  Google Scholar 

  46. Schindl A, Merwald H, Schindl L, Kaun C, Wojta J (2003) Direct stimulatory effect of low-intensity 670 nm laser irradiation on human endothelial cell proliferation. Br J Dermatol 148(2):334–336

    Article  PubMed  CAS  Google Scholar 

  47. Seifi M, Shafeei HA, Daneshdoost S, Mir M (2007) Effects of two types of low-level laser wave lengths (850 and 630 nm) on the orthodontic tooth movements in rabbits. Lasers Med Sci 22(4):261–264

    Article  PubMed  Google Scholar 

  48. Amaral AC, Parizotto NA, Salvini TF (2001) Dose-dependency of low-energy HeNe laser effect in regeneration of skeletal muscle in mice. Lasers Med Sci 16(1):44–51

    Article  PubMed  CAS  Google Scholar 

  49. Yilmaz S, Kuru B, Kuru L et al (2002) Effect of galium arsenide diode laser on human periodontal disease: a microbiological and clinical study. Lasers Surg Med 30:60–66. doi:10.1002/lsm.10010

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

This work was supported by the National Nature Science Foundation of China (grant number 81271178).

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to S. J. Zou.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Cheng, Y., Chen, J.W., Ge, M.K. et al. Efficacy of adjunctive laser in non-surgical periodontal treatment: a systematic review and meta-analysis. Lasers Med Sci 31, 151–163 (2016). https://doi.org/10.1007/s10103-015-1795-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10103-015-1795-5

Keywords

Navigation