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Additional effects of aPDT on nonsurgical periodontal treatment with doxycycline in type II diabetes: a randomized, controlled clinical trial

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Abstract

The association of doxycycline and periodontal treatment in non-controlled diabetes mellitus (DM) has shown positive results on clinical and metabolic parameters. Antimicrobial photodynamic therapy (aPDT) is a local and painless antimicrobial treatment that can be applied in periodontal treatment without systemic risks. The aim of this study was to evaluate the potential improvement of aPDT on clinical and metabolic effects in patients with type 2 diabetes mellitus in conjunction with nonsurgical periodontal treatment plus doxycycline. Thirty patients with type 2 diabetes and diagnosis of chronic periodontitis were treated with scaling and root planning (SRP; N = 15) or SRP plus phenothiazine chloride photosensitizer-induced aPDT (SRP + aPDT, N = 15). Patients of both groups took doxycycline (100 mg/day) for 2 weeks and plaque index, bleeding on probe (BOP), probing pocket depth (PPD), suppuration, clinical attachment level (CAL), and glycated hemoglobin levels (HbA1c) were measured at baseline and 3 months after therapy. An improvement in clinical parameters such as PPD, CAL, S, and BOP between groups was observed but without statistical significance (p > 0.05). Intragroup analysis showed a significant reduction of HbA1c (8.5 ± 0.9 to 7.5 ± 0.1, p < 0.01) in the SRP + aPDT group. The differences of HbA1c between baseline and 3 months were greater for the SRP + aPDT (11.4 %) than SRP (10 %) (0.87 ± 0.9 and 0.4 ± 0.84 respectively; p < 0.05). A single application of the aPDT as an adjunct to periodontal treatment did not show additional benefits in the clinical parameters but resulted in a slight greater decrease in HbA1c.

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Notes

  1. Florida Probe, Gainesville, FL

  2. Labtest Sistemas para Diagnóstico, Lagoa Santa, MG, Brazil

  3. Gracey curettes, Hu-Friedy Instruments, Chicago, IL

  4. Cavitron, Dentsply, York, PA

  5. Vibramicina 100 mg/Pfizer, Guarulhos, SP, Brasil

  6. Helbo Therapielaser, Helbo Photodynamic Systems, Grieskirchen, Austria

  7. Helbo Blue, Helbo Photodynamic Systems

  8. Helbo 3D Pocket Probe, Helbo Photodynamic Systems

  9. SPSS, Chicago, IL

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Acknowledgments

The authors thank the State of São Paulo Research Foundation (FAPESP; protocol number 06/04600-9) for its financial support of this study.

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Authors and Affiliations

  1. School of Dentistry, Tiradentes University, Aracaju, SE, Brazil

    Guilherme de Oliveira Macedo

  2. Department of Buco-Maxillo-Facial Surgery, Traumatology and Periodontology, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil

    Arthur B. Novaes Jr., Sérgio L. S. Souza, Mário Taba Jr., Daniela B. Palioto & Márcio F. M. Grisi

  3. Faculdade de Odontologia, Universidade Tiradentes, Rua Siriri 263, 49010-450, Aracaju, SE, Brazil

    Guilherme de Oliveira Macedo

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  1. Guilherme de Oliveira Macedo
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  2. Arthur B. Novaes Jr.
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  3. Sérgio L. S. Souza
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  4. Mário Taba Jr.
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  5. Daniela B. Palioto
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  6. Márcio F. M. Grisi
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Correspondence to Guilherme de Oliveira Macedo.

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Macedo, G.O., Novaes, A.B., Souza, S.L.S. et al. Additional effects of aPDT on nonsurgical periodontal treatment with doxycycline in type II diabetes: a randomized, controlled clinical trial. Lasers Med Sci 29, 881–886 (2014). https://doi.org/10.1007/s10103-013-1285-6

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  • DOI: https://doi.org/10.1007/s10103-013-1285-6

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