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Zika virus: epidemiology, clinical aspects, diagnosis, and control of infection

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Abstract

Zika virus (ZIKV) is an emerging pathogen of huge public health significance to human beings. Although majority of infections are benign with self-limiting symptoms, the recent outbreak has established an association with the increased incidence of some congenital anomalies such as microcephaly. In other words, due to the large extent of the virus and mosquito vectors, the infection has become a thoughtful health problem for human societies, though now, there are no antiviral therapies or vaccines against this virus. In spite of extensive research carried out by scientists, not so much information has been gathered about this viral infection. In the current review, we prepared an overview of the remarkable progress made in understanding about the epidemiology, immunology, clinical presentation, and diagnosis methods of ZIKV infection.

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Acknowledgments

The authors thank Dr. Evangeline Foronda in the Research Administration Department of Babol University of Medical Sciences for English editing the manuscript.

Specific author contributions

S.E and H. N conceived the study; S. E, M.J., J.M.R, and A.K. collected all data; A.K.,V.K., S.K., and S. E drafted the manuscript; and all authors commented on the drafts of the manuscript and approved the final draft of the paper.

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Authors and Affiliations

  1. Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran

    Ahmad Karkhah, Hamid Reza Nouri & Sohrab Kazemi

  2. Student Research Committee, School of Medicine, Babol University of Medical Sciences, Babol, Iran

    Ahmad Karkhah

  3. Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran

    Mostafa Javanian, Jila Masrour-Roudsari & Soheil Ebrahimpour

  4. Scientist Biopharmaceutical Development Medimmune, Gaithersburg, MD, 20878, USA

    Veerendra Koppolu

Authors
  1. Ahmad Karkhah
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  2. Hamid Reza Nouri
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  3. Mostafa Javanian
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  4. Veerendra Koppolu
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  5. Jila Masrour-Roudsari
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  6. Sohrab Kazemi
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  7. Soheil Ebrahimpour
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Corresponding author

Correspondence to Soheil Ebrahimpour.

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The authors declare that they have no conflict of interest.

Ethical approval

This study received the approval from the Babol University of Medical Science Ethical Committee.

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There is no informed consent for this systematic review article.

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Karkhah, A., Nouri, H.R., Javanian, M. et al. Zika virus: epidemiology, clinical aspects, diagnosis, and control of infection. Eur J Clin Microbiol Infect Dis 37, 2035–2043 (2018). https://doi.org/10.1007/s10096-018-3354-z

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  • DOI: https://doi.org/10.1007/s10096-018-3354-z

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