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A double-blind comparative study of Chinese herbal medicine Jinlianqingre Effervescent Tablets in combination with conventional therapy for the treatment of uncomplicated hand, foot, and mouth disease

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Abstract

Chinese herbal medicine Jinlianqingre Effervescent Tablets (JET) are the recommended control measure for uncomplicated hand, foot, and mouth disease (HFMD) by the Ministry of Health of China. However, high-quality evidence to support this recommendation is limited. A total of 288 patients ranging in age from 1 to 13 years were randomly assigned to JET in combination with conventional therapy (mainly including the reduction of temperature by applying physical cooling paste or warm bathing), or conventional therapy with placebo group for 7 days. The objective was to test the hypothesis that JET combination therapy is more effective than conventional therapy for uncomplicated HFMD. A randomized, double-blind, placebo-controlled trial was designed. Our study showed that, compared with conventional therapy, the median time to fever resolution was significantly shorter in the JET combination therapy (8 vs. 80 h; p < 0.0001); the risk of fever resolution increased in the JET combination therapy [hazard ratio, 19.8; 95 % confidence interval (CI), 12.8 to 30.7]; the median healing time of rash or oral ulcer was significantly shorter in the JET combination therapy (14 vs. 74 h; p < 0.0001); and the median symptom score for skin or oral mucosa lesions improved more rapidly in the JET combination therapy during the follow-up period. The median duration of hospital stay was 6 days in the JET combination therapy and 7 days in the conventional therapy (p < 0.0001). No significant adverse events and complications were found in both groups. The addition of JET to conventional therapy reduced fever clearance time, healing time of skin or oral mucosa lesions, and duration of hospital stay in children with uncomplicated HFMD.

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Acknowledgments

The authors thank the centers’ coordinators for their valuable contribution. The authors also appreciate the approval of Tianjin Zhong Sheng Hai Tian Pharmaceutical Co. Ltd. for the medication supply.

Supported by: the State Administration of Traditional Chinese Medicine (SATCM) of China provided peer-reviewed funding for this study (no. 200907001-3). The sponsor of this study had no role in the study design, in collecting, analyzing, and interpreting the data, or the writing of the report. The corresponding author had full access to all the study data and had final responsibility in the decision to submit the publication.

Conflict of interest

The authors declare that they have no competing interests in relation to this article. T. Zhao and J. Li are employees of Tianjin Zhong Sheng Hai Tian Pharmaceutical Co. Ltd.; they are not involved in the funded project.

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Authors and Affiliations

  1. China Academy of Chinese Medical Sciences, Beijing, 100700, China

    B.-Y. Liu

  2. Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China

    L.-Y. He, S.-Y. Yan, Y. Liu & Y.-Y. Wang

  3. The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei City, Anhui Province, China

    G.-L. Zhang

  4. Beijing Children’s Hospital, Beijing, China

    C.-S. Zhao & X.-L. Wang

  5. Tianjin Infectious Disease Hospital, Tianjin, China

    Y.-Q. Mi & Y.-M. Liu

  6. Tangshan Infectious Disease Hospital, Tangshan City, Hebei Province, China

    Y. Li, C.-P. Li, Y.-H. Kou & Y. Li

  7. Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu City, Sichuan Province, China

    K. Chang, X.-L. Meng & X.-J. Sun

  8. Tianjin Zhong Sheng Hai Tian Pharmaceutical Co. Ltd., Tianjin, China

    T. Zhao & J. Li

Authors
  1. L.-Y. He
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  2. G.-L. Zhang
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  3. S.-Y. Yan
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  4. Y. Liu
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  5. C.-S. Zhao
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  6. X.-L. Wang
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  7. Y. Li
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  8. Y.-Q. Mi
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  9. Y.-M. Liu
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  10. C.-P. Li
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  11. Y.-H. Kou
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  12. Y. Li
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  13. K. Chang
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  14. X.-L. Meng
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  15. X.-J. Sun
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  16. T. Zhao
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  17. J. Li
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  18. Y.-Y. Wang
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  19. B.-Y. Liu
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Corresponding author

Correspondence to B.-Y. Liu.

Additional information

Liyun He and Guoliang Zhang contributed equally to this work.

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He, LY., Zhang, GL., Yan, SY. et al. A double-blind comparative study of Chinese herbal medicine Jinlianqingre Effervescent Tablets in combination with conventional therapy for the treatment of uncomplicated hand, foot, and mouth disease. Eur J Clin Microbiol Infect Dis 33, 1429–1437 (2014). https://doi.org/10.1007/s10096-014-2085-z

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  • DOI: https://doi.org/10.1007/s10096-014-2085-z

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