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Regional variations in quinolone use in France and associated factors

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Abstract

The purpose of this study was to investigate geographic variations in the use of quinolones in France and their associated factors. All reimbursement claims of antimicrobials were collected for 90 % of the French population for the year 2007. Dispensed quantities were then converted into defined daily doses (DDD) and adjusted for the age structure of the national population. Correlations between quinolone use and total antimicrobial use and some morbidity and socio-economic factors were studied using Spearman’s rank correlation coefficients. On average, 2.05 DDD of quinolones per 1,000 inhabitants per day (DID) were dispensed in 2007 in France, accounting for 10.2 % of the total antimicrobial consumption in adults. A 40 % variation was observed between the regions with the lowest (1.73 DID) and the highest use (2.44 DID). This variation was more important for anti-pneumococcal quinolones than for quinolones directed against urinary tract infections (coefficients of variation: 26 vs. 6 %). Quinolone use was correlated with some regional socio-economic factors (unemployment, growth domestic product, health expenditures) and physician density, but was independent of the total antimicrobial use. After adjustment for age, large variations in quantitative and qualitative quinolone use were observed across French regions, especially for anti-pneumococcal fluoroquinolones. These results, though not controlled for potential epidemics variations, argue in favour of a possible improvement in quinolone prescribing to be achieved in some regions.

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Acknowledgements

This work did not receive any specific funding.

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The authors have no conflicts of interest regarding this study.

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Authors and Affiliations

  1. INSERM, UMR 1027 Epidémiologie et Analyses en Santé Publique: Risques, Maladies Chroniques, Handicaps, Université de Toulouse, UPS Toulouse 3, 37 Allées Jules Guesde, 31000, Toulouse, France

    A. Gallini & F. Taboulet

  2. Université de Toulouse, UPS Toulouse 3, Toulouse, France

    A. Gallini & F. Taboulet

  3. Faculté des Sciences Pharmaceutiques, Laboratoire de Droit Pharmaceutique et d’Economie de la Santé, Université de Toulouse, UPS Toulouse 3, Toulouse, France

    F. Taboulet

  4. Caisse Nationale d’Assurance Maladie des Travailleurs Salariés (CNAMTS), Échelon Régional du Service Médical Midi-Pyrénées, Toulouse, France

    R. Bourrel

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  1. A. Gallini
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  2. F. Taboulet
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  3. R. Bourrel
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Correspondence to A. Gallini.

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Gallini, A., Taboulet, F. & Bourrel, R. Regional variations in quinolone use in France and associated factors. Eur J Clin Microbiol Infect Dis 31, 2911–2918 (2012). https://doi.org/10.1007/s10096-012-1640-8

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  • DOI: https://doi.org/10.1007/s10096-012-1640-8

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