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Clinical and microbiological characteristics of urine culture-confirmed genitourinary tuberculosis at medical centers in Taiwan from 1995 to 2007

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Abstract

All patients with urine culture-confirmed genitourinary tuberculosis (GUTB) diagnosed between 1995 and 2007 at two medical centers in northern Taiwan were included in this retrospective study. Genotypes of 48 preserved Mycobacterium tuberculosis (MTB) isolates from these patients were determined by spoligotyping and double repetitive element PCR (DRE-PCR) analysis. Among the 64 patients, 38 (59.4%) were male with a mean ±SD age of 60.3 ± 16.1 years old. The overall mortality rate was 26.2%. Poor prognostic factors included age over 65 years (HR = 4.03; 95%; CI: 1.27–12.76), cardiovascular disease (HR = 5.96; 95% CI: 1.98–17.92), receiving steroids (HR = 10.16; 95% CI: 2.27–45.47), not being treated (HR 4.81; 95% CI 1.12–20.67). Spoligotyping and DRE-PCR of the 48 MTB isolates revealed that 20 (41.7%) belonged to the Beijing family and 40 (83.3%) had a clustering pattern. Identification of a Beijing family isolate was not correlated with drug resistance or mortality. Clustering strains were likely to be resistant to isoniazid (OR = 4.71; 95% CI: 1.10 to 23.53). In this study of patients with urine culture-confirmed GUTB, age and coexisting diseases were independently associated with an unfavorable outcome. The Beijing family was the dominant genotype of GUTB isolates, but did not correlate with drug resistance or outcome.

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Funding

Funding for this study was provided by the Institute for Biotechnology and Medicine Industry (DOH97-DC-1501)

Conflict of interest

None of the authors has anything to declare.

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Authors and Affiliations

  1. Division of Pulmonary Medicine, Department of Internal Medicine, Taipei Medical University-Wan Fang Hospital, Taipei, Taiwan

    H.-L. Hsu & M.-C. Yu

  2. Department of Laboratory Medicine, Taipei Medical University—Wan Fang Hospital, Taipei, Taiwan

    F.-L. Yu & J.-C. Lee

  3. Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch, Yun-Lin, Taiwan

    C.-H. Chou

  4. Department of Intensive Care Medicine, Chi-Mei Medical Center, Liouying, Tainan, Taiwan

    C.-C. Lai & C.-K. Tan

  5. Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan

    P.-C. Yang & P.-R. Hsueh

  6. Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, No.7, Chung-Shan South Road, 100, Taipei, Taiwan

    P.-R. Hsueh

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  1. H.-L. Hsu
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  2. C.-C. Lai
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  3. M.-C. Yu
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  4. F.-L. Yu
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  5. J.-C. Lee
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  6. C.-H. Chou
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  7. C.-K. Tan
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  9. P.-R. Hsueh
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Correspondence to P.-R. Hsueh.

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Hsu, HL., Lai, CC., Yu, MC. et al. Clinical and microbiological characteristics of urine culture-confirmed genitourinary tuberculosis at medical centers in Taiwan from 1995 to 2007. Eur J Clin Microbiol Infect Dis 30, 319–326 (2011). https://doi.org/10.1007/s10096-010-1083-z

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  • DOI: https://doi.org/10.1007/s10096-010-1083-z

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