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Factor V Leiden mutation and patent foramen ovale in ischemic stroke

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Abstract.

We report a 47-years-old male with ischemic stroke, whose arteriographic and echocardiographic investigations did not reveal any steno-occlusive arterial disease or embolic source from the left cardiac chambers. A transesophageal echocardiogram showed a patent foramen ovale (PFO), whilst laboratory screening for coagulation abnormalities showed heterozygosity for factor V Leiden mutation. The significance of the association of PFO with factor V Leiden mutation is discussed as a possible cause of ischemic stroke through paradoxical embolism from a venous source. The high prevalence of these two conditions in the general population is emphasized and the indication for anticoagulant therapy is discussed.

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Received: 7 December 2001 / Accepted in revised form: 16 July 2002

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Bezzi, G., Bolzani, W., Compagnoni, V. et al. Factor V Leiden mutation and patent foramen ovale in ischemic stroke. Neurol Sci 23, 229–231 (2002). https://doi.org/10.1007/s100720200046

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  • DOI: https://doi.org/10.1007/s100720200046

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