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Current application of cannabidiol (CBD) in the management and treatment of neurological disorders

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Abstract

Cannabidiol (CBD), which is nonintoxicating pharmacologically relevant constituents of Cannabis, demonstrates several beneficial effects. It has been found to have antioxidative, anti-inflammatory, and neuroprotective effects. As the medicinal use of CBD is gaining popularity for treatment of various disorders, the recent flare-up of largely unproven and unregulated cannabis-based preparations on medical therapeutics may have its greatest impact in the field of neurology. Currently, as lot of clinical trials are underway, CBD demonstrates remarkable potential to become a supplemental therapy in various neurological conditions. It has shown promise in the treatment of neurological disorders such as anxiety, chronic pain, trigeminal neuralgia, epilepsy, and essential tremors as well as psychiatric disorders. While recent FDA-approved prescription drugs have demonstrated safety, efficacy, and consistency enough for regulatory approval in spasticity in multiple sclerosis (MS) and in Dravet and Lennox-Gastaut Syndromes (LGS), many therapeutic challenges still remain. In the current review, the authors have shed light on the application of CBD in the management and treatment of various neurological disorders.

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Authors and Affiliations

  1. Department of Neurosurgery, Desert Regional Medical Center, Palm Springs, CA, USA

    Brian Fiani

  2. Miller School of Medicine, University of Miami, Miami, FL, USA

    Kasra John Sarhadi

  3. New York University School of Medicine, New York, NY, USA

    Marisol Soula

  4. Department of Neurology, University of New Mexico, Albuquerque, NM, USA

    Atif Zafar

  5. Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA

    Syed A. Quadri

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Fiani, B., Sarhadi, K.J., Soula, M. et al. Current application of cannabidiol (CBD) in the management and treatment of neurological disorders. Neurol Sci 41, 3085–3098 (2020). https://doi.org/10.1007/s10072-020-04514-2

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