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New insights into the role of neuron-specific enolase in tic disorders

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Abstract

Objective

Neuron-specific enolase (NSE) has been suggested for demonstrating brain metabolism in neuropsychiatric disorders. This study assessed serum NSE levels in patients with tic disorders (TD).

Methods

In this retrospective case-control study, we investigated whether NSE levels were increased in TD patients. Then, the influencing factors and correlations between NSE levels and clinical features were analyzed. Finally, we tested its diagnostic value for identifying tic severity.

Results

NSE levels were increased in TD patients, although no statistically significant difference was present between transient TD, chronic TD, and Tourette syndrome. Factors influencing NSE levels assessed by multiple linear regression were the Yale Global Tic Severity Scale (YGTSS) global severity scores and gender. There were significant correlations between NSE levels and tic severity. The optimal cut-off value to distinguish mild tics from moderate-severe tics estimated by receiver operating characteristics curve was 24.95 ng/ml (AUC = 0.683).

Conclusion

Our findings suggested that NSE may be a significant biomarker in TD but should be confirmed in further investigation.

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Authors and Affiliations

  1. Shanghai Jiao Tong University School of Medicine, 227 Chongqing Road, Shanghai, 200025, People’s Republic of China

    Juanjuan Hao

  2. Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, People’s Republic of China

    Xin Zhang, Keyu Jiang & Min Wu

Authors
  1. Juanjuan Hao
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  2. Xin Zhang
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  3. Keyu Jiang
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  4. Min Wu
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Contributions

Authors Juanjuan Hao and Min Wu designed the study, collected and analyzed the data, and wrote the manuscript. Authors Xin Zhang and Keyu Jiang made a contribution on revising the manuscript for content. All authors approved the final manuscript.

Corresponding author

Correspondence to Min Wu.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This study was approved by the Xinhua Hospital Ethics Committee affiliated to Shanghai JiaoTong University School of Medicine (Approval No. XHEC-D-2018-047).

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Hao, J., Zhang, X., Jiang, K. et al. New insights into the role of neuron-specific enolase in tic disorders. Neurol Sci 40, 1167–1172 (2019). https://doi.org/10.1007/s10072-019-03811-9

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  • DOI: https://doi.org/10.1007/s10072-019-03811-9

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