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Effect of repetitive transcranial magnetic stimulation on auditory function following acoustic trauma

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Abstract

Repetitive transcranial magnetic stimulation (rTMS) is one form of non-invasive brain stimulation and increasingly shows neuroprotection in multiple neurological disorders. However, the potential of rTMS for protective action on auditory function following acoustic trauma has not been investigated. Here, we examined effect of TMS on hearing conservation, neurons survival and brain-derived neurotrophin factor (BDNF) expression in the cochlea and auditory cortex following acoustic trauma in rats. Wistar rats were exposed to intense pure tone noise (10 kHz, 120 dB SPL for 2 h) followed by rTMS treatment or sham treatment (handling control) daily for 14 days. Auditory brainstem response revealed there was no significant difference in hearing threshold shifts between rTMS- and sham-treated rats, although rTMS-treated rats showed less neuron loss in the auditory cortex in comparison with sham rats. Additionally, acoustic trauma increased BDNF expression in the cochlea and auditory cortex, and this elevation could be attenuated by rTMS treatment. Our results suggest present regiment of rTMS does not protect hearing against acoustic trauma, but maybe have implications for tinnitus treatment.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (81200743 and 81570916), Guangdong Natural Science Foundation (2015A030313041) and the Fundamental Research Funds for the Central Universities (13ykpy28).

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    Authors and Affiliations

    1. Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 West Yan Jiang Road, Guangzhou, 510120, China

      Haidi Yang, Hao Xiong, Yongkang Ou, Yaodong Xu, Jiaqi Pang, Lan Lai & Yiqing Zheng

    2. Institute of Hearing and Speech-Language Science, Sun Yat-sen University, Guangzhou, China

      Haidi Yang, Hao Xiong, Yongkang Ou, Yaodong Xu, Jiaqi Pang, Lan Lai & Yiqing Zheng

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    1. Haidi Yang
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    Correspondence to Yiqing Zheng.

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    H. Yang and H. Xiong contributed equally to this work.

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    Yang, H., Xiong, H., Ou, Y. et al. Effect of repetitive transcranial magnetic stimulation on auditory function following acoustic trauma. Neurol Sci 37, 1511–1516 (2016). https://doi.org/10.1007/s10072-016-2603-0

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    • DOI: https://doi.org/10.1007/s10072-016-2603-0

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