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Effects of slow repetitive transcranial magnetic stimulation in patients with corticobasal syndrome

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Abstract

Corticobasal syndrome is characterized by asymmetric cortical sensorimotor dysfunction and parkinsonism; an altered cortical excitability has been reported. We explored with transcranial magnetic stimulation the motor cortical excitability in corticobasal syndrome, and the effects of slow repetitive transcranial magnetic stimulation. With transcranial magnetic stimulation, we studied two corticobasal syndrome patients. We determined bilaterally from the first dorsal interosseous muscle: relaxed threshold, and contralateral and ipsilateral silent period. We also evaluated the contralateral silent period after active/sham slow repetitive transcranial magnetic stimulation on the most affected side. At T0 the silent period was bilaterally short. On the most affected side, active slow repetitive transcranial magnetic stimulation induced a short lasting prolongation of the contralateral silent period. In corticobasal syndrome, transcranial magnetic stimulation showed a reduction cortical inhibitory phenomenon potentially reversed transiently by slow repetitive transcranial magnetic stimulation.

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Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Clinica Neurologica, Azienda Ospedaliero Universitaria “Maggiore della Carità”, C.so Mazzini 18, 28100, Novara, Italy

    Carlo Civardi & Francesco Monaco

  2. Neurologia Riabilitativa, Fondazione Maugeri IRCCS, Veruno, Italy

    Fabrizio Pisano & Carmen Delconte

  3. Department of Neurology, ASL TO4, Chivasso, Italy

    Alessandra Collini

Authors
  1. Carlo Civardi
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  2. Fabrizio Pisano
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  3. Carmen Delconte
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  4. Alessandra Collini
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  5. Francesco Monaco
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Corresponding author

Correspondence to Carlo Civardi.

Additional information

Francesco Monaco: Deceased.

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Civardi, C., Pisano, F., Delconte, C. et al. Effects of slow repetitive transcranial magnetic stimulation in patients with corticobasal syndrome. Neurol Sci 36, 1007–1009 (2015). https://doi.org/10.1007/s10072-015-2115-3

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  • DOI: https://doi.org/10.1007/s10072-015-2115-3

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