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Association between TNF-α promoter −308 A/G polymorphism and Alzheimer’s disease: a meta-analysis

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Abstract

The aim of this study was to determine whether the tumor necrosis factor-α (TNF-α) promoter −308 A/G polymorphism is associated with susceptibility to Alzheimer’s disease (AD) in multi-ethnic populations. MEDLINE and EMBASE databases and manual literature search were used to identify published articles in which TNF-α polymorphism was determined in AD patients and control subjects. Meta-analysis was conducted on the association between the TNF-α −308 A/G polymorphism and AD using allele contrast and the recessive, dominant, and additive models. A total of 16 studies involving 3,826 AD patients and 4,327 control subjects were examined. The meta-analysis showed no association between the TNF-α −308 A allele and AD when all the subjects were considered [odds ratio (OR) = 1.275, 95 % CI 0.966–1.685, p = 0.087]. After stratification by ethnicity, the meta-analysis indicated that the A allele is significantly associated with AD in East Asian (OR = 1.743, 95 % CI 1.256–2.418, p = 0.001), but not in the European (OR = 0.963, 95 % CI 0.822–1.128, p = 0.637) or Middle Eastern populations (OR = 3.921, 95 % CI 0.411–37.42, p = 0.235). Meta-analysis under dominant, recessive, and additive models also showed a similar pattern of results as with the A allele. This meta-analysis shows that the TNF-α −308 A/G polymorphism may represent a significant risk factor for AD in East Asians but not in the European or Middle Eastern populations.

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Acknowledgments

This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

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The authors have no financial or non-financial conflict of interest to declare.

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Authors and Affiliations

  1. Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126-1 ga, Anam-dong 5-ga, Seongbuk-gu, Seoul, 136-705, Korea

    Young Ho Lee, Sung Jae Choi, Jong Dae Ji & Gwan Gyu Song

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  1. Young Ho Lee
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Correspondence to Young Ho Lee.

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Lee, Y.H., Choi, S.J., Ji, J.D. et al. Association between TNF-α promoter −308 A/G polymorphism and Alzheimer’s disease: a meta-analysis. Neurol Sci 36, 825–832 (2015). https://doi.org/10.1007/s10072-015-2102-8

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  • DOI: https://doi.org/10.1007/s10072-015-2102-8

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