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Contact heat-evoked potentials as a useful means in patients with Guillain–Barré syndrome

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Abstract

Few objective methods have been utilized to identify the small myelinated fiber impairment causing neuropathic pain in Guillain–Barré syndrome (GBS). In this study, contact heat-evoked potentials (CHEPs) were applied to study the nociceptive pathway in GBS. Sixty GBS patients and fifty healthy controls were enrolled. The 60 GBS patients were divided into two subgroups presenting with or without subjective lower limb paresthesia (21/39). CHEPs were recorded at Cz and Pz with a peak thermal stimuli of 47 °C applied to the skin of the leg above the internal malleolus (AIM) and of the waist at the anterior superior iliac spine (ASIS) level. The N2 latency and N2–P2 amplitude of CHEPs were compared. When the skin of the leg AIM was stimulated, the N2 latency was significantly postponed (425.23 ± 28.66 vs. 402.30 ± 19.48 ms, P < 0.05) and the N2–P2 amplitude significantly decreased in GBS patients as compared to controls (32.71 ± 7.49 vs. 42.77 ± 8.71 μV, P < 0.05). Slower nerve conduction velocity was observed in GBS patients (11.84 ± 1.45 vs. 13.28 ± 0.66 ms, P < 0.05). However, no differences in N2 latency or N2–P2 amplitude were detected between the two subgroups of GBS patients with or without subjective lower limb paresthesia (P all >0.05). Moreover, there were no differences in N2 latency and N2–P2 amplitude among different groups when the waist was stimulated at the ASIS level. Our study suggested that CHEPs could be utilized as an objective and non-invasive tool to detect small myelinated fiber damage in GBS patients, especially for those without subjective paresthesia.

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Acknowledgments

The study was supported by the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry, the National Science Foundation (30800356, 81271409), Tianjin Science Foundation (07JCYBJC16200), and the Scientific Research Foundation for Talented Scholars, Tianjin Medical University General Hospital.

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The authors state that they have no conflict of interest.

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Correspondence to Yuanrong Yao.

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Zhang, C., Xie, B., Li, X. et al. Contact heat-evoked potentials as a useful means in patients with Guillain–Barré syndrome. Neurol Sci 35, 1209–1214 (2014). https://doi.org/10.1007/s10072-014-1682-z

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  • DOI: https://doi.org/10.1007/s10072-014-1682-z

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