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Intractable focal epilepsy contralateral to the side of facial atrophy in Parry–Romberg syndrome

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Abstract

We report an unusual case of Parry–Romberg syndrome in which medically refractory focal epilepsy with ongoing epilepsia partialis continua (EPC) arose from the hemisphere contralateral to the side of facial atrophy. Unilateral cerebral involvement was confirmed by multi-modal brain imaging, as well as by electroencephalography (EEG) and magnetoencephalography (MEG). While in many cases of Parry–Romberg syndrome, the side of cerebral involvement is ipsilateral to that of the cutaneous lesion, these “discordant” exceptions imply that other yet undefined mechanisms may be responsible for the distribution of the cutaneous and cerebral pathologies.

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Acknowledgments

Informed consent was obtained from the patient for the publication of his photograph and historical details in this paper.

Conflict of interest

Dr. Kakisaka, Dr. So, Dr. Jones, Dr. Wang, Dr. Mosher, Dr. Burgess report no disclosures. Dr. Alexopoulos have received research support from UCB and Pfizer Inc.

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Authors and Affiliations

  1. Department of Neurology, Epilepsy Center, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA

    Yosuke Kakisaka, Norman K. So, Zhong I. Wang, John C. Mosher, Andreas V. Alexopoulos & Richard C. Burgess

  2. Department of Pediatrics, Tohoku University School of Medicine, Sendai, Japan

    Yosuke Kakisaka

  3. Department of Neuroradiology, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA

    Stephen E. Jones

Authors
  1. Yosuke Kakisaka
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  2. Norman K. So
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  3. Stephen E. Jones
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  4. Zhong I. Wang
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  5. John C. Mosher
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  6. Andreas V. Alexopoulos
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  7. Richard C. Burgess
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Corresponding author

Correspondence to Norman K. So.

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Kakisaka, Y., So, N.K., Jones, S.E. et al. Intractable focal epilepsy contralateral to the side of facial atrophy in Parry–Romberg syndrome. Neurol Sci 33, 165–168 (2012). https://doi.org/10.1007/s10072-011-0643-z

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  • DOI: https://doi.org/10.1007/s10072-011-0643-z

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