Skip to main content
SpringerLink
Log in

Harmful effect of kainic acid on brain ischemic damage is not related to duration of status epilepticus

  • Brief Communication
  • Published:
Neurological Sciences Aims and scope Submit manuscript

Abstract

Status epilepticus is common in infants and may have long-term consequences on the brain persisting into adulthood. Vascular ischemia is a common cause of stroke in adulthood. The extent of stroke in 15-day-old rats is larger when previously exposed to kainic acid-induced status epilepticus. In this paper, we assess whether shortening the duration of seizures modifies subsequent susceptibility to middle cerebral artery occlusion. We administered pentobarbital 50 mg/kg to abort seizures after 1 h. Although administration of pentobarbital aborted seizures, it had no effect on volume of infarction following ischemia. This study indicates that there is dissociation between stopping status epilepticus and modifying its long-term consequences.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Koh S, Storey TW, Santos TC, Mian AY, Cole AJ (1999) Early-life seizures in rats increase susceptibility to seizure-induced brain injury in adulthood. Neurology 53:915–921

    CAS  PubMed  Google Scholar 

  2. Hauser WA, Rich SS, Annegers JF, Anderson VE (1990) Seizure recurrence after a 1st unprovoked seizure: an extended follow-up. Neurology 40:1163–1170

    CAS  PubMed  Google Scholar 

  3. Shinnar S, Pellock JM, Moshe SL, Maytal J, O’Dell C, Driscoll SM et al (1997) In whom does status epilepticus occur: age-related differences in children. Epilepsia 38:907–914

    Article  CAS  PubMed  Google Scholar 

  4. Feigin VL (2005) Stroke epidemiology in the developing world. Lancet 365:2160–2161

    Article  PubMed  Google Scholar 

  5. Haut SR, Veliskova J, Moshe SL (2004) Susceptibility of immature and adult brains to seizure effects. Lancet Neurol 3:608–617

    Article  PubMed  Google Scholar 

  6. Giorgi FS, Malhotra S, Hasson H, Velísková J, Rosenbaum D, Moshé SL (2005) Effects of status epilepticus early in life on susceptibility to ischemic injury in adulthood. Epilepsia 46:490–498

    Article  PubMed  Google Scholar 

  7. Hasson H, Kim M, Moshe SL (2008) Effective treatments of prolonged status epilepticus in developing rats. Epilepsy Behav 13:62–69

    Article  PubMed  Google Scholar 

  8. Velisek L, Moshe SL (2002) Effects of brief seizures during development. Prog Brain Res 135:355–364

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

Dr. Hasson is an NSADA trainee supported by K12 NS048856. Supported by RO1 NS20253 from NINDS and the Heffer Family Foundation. S.L.M. is a recipient of a Martin A. and Emily L. Fischer Fellowship in Neurology and Pediatrics.

Conflict of interest statement

None of the coauthors have any financial disclosures to disclose.

Author information

Authors and Affiliations

  1. Saul R. Korey Department of Neurology, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY, USA

    Henry Hasson & Solomon L. Moshé

  2. Department of Pediatrics, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY, USA

    Henry Hasson & Solomon L. Moshé

  3. Department of Neurology, SUNY Downstate Medical Center, Brooklyn, NY, USA

    Samit Malhotra & Daniel M. Rosenbaum

  4. Section of Neurology, Department of Neuroscience, University of Pisa, Pisa, Italy

    Filippo S. Giorgi

  5. Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY, USA

    Solomon L. Moshé

  6. 948 48th street, Brooklyn, NY, USA

    Henry Hasson

Authors
  1. Henry Hasson
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Samit Malhotra
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Filippo S. Giorgi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Daniel M. Rosenbaum
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Solomon L. Moshé
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Henry Hasson.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hasson, H., Malhotra, S., Giorgi, F.S. et al. Harmful effect of kainic acid on brain ischemic damage is not related to duration of status epilepticus. Neurol Sci 31, 103–105 (2010). https://doi.org/10.1007/s10072-009-0115-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10072-009-0115-x

Keywords

Search

Navigation