Abstract
The objective of this study was to determine the effects of sanshoamides and capsaiciniods on plasma and liver lipid levels and the mRNA expression levels of key receptors involved in cholesterol metabolism in hyperlipidemic rats. A total of 56 three-week-old female Sprague–Dawley rats were assigned to 7 treatment groups based on initial body weight (n = 8 rats per group). With certain combinations of sanshoamides and capsaicinoids significantly increased food intake, reduced lipid levels in blood and liver, improved histological characteristics of a fatty liver, down regulated mRNA expression levels of cholesterol 7-alpha-hydroxylase (CYP7A1), 3-hydroxyl-3-methylglutary CoA (HMG-CoA) and Farnesoid X Receptor (FXR) in liver and apical sodium-dependent bile acid transporter, Ileal Bile Acid Binding Protein and FXR in the ileum in hyperlipidemic rats. These results indicated that dietary supplementation with sanshoamides and capsaicinoids reduced blood lipid levels and improved cholesterol metabolism in hyperlipidemic rats.
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Abbreviations
- HMG-CoA:
-
3-hydroxyl-3-methylglutary CoA
- CYP7A1:
-
Cholesterol 7 alpha-hydroxylase
- FXR:
-
Farnesoid X Receptor
- IBABP:
-
Ileal Bile Acid Binding Protein
- ASBT:
-
Apical sodium-dependent bile acid transporter
- LDL-C:
-
Low-density lipoprotein cholesterol
- TC:
-
Total cholesterol
- TG:
-
Total triglycerides
- HDL-C:
-
High-density lipoprotein cholesterol
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Acknowledgements
The authors would like to thank Lulin Tan, Hongjia Lu, Yun Liu, Qingqing Liu, and Qianqian Wang for their assistance with the experiments. This study was supported by Scientific and Technological Project of Guizhou Provence ([2014] 6016), and Construction Project of Innovative Talents Base of Guizhou Provence ([2016] 22).
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Chen, Z., Liu, Y., Wang, H. et al. Effects of sanshoamides and capsaicinoids on plasma and liver lipid metabolism in hyperlipidemic rats. Food Sci Biotechnol 28, 519–528 (2019). https://doi.org/10.1007/s10068-018-0466-2
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DOI: https://doi.org/10.1007/s10068-018-0466-2