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In vitro and in vivo anti-tumor effects of oriental herbal mixtures

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Abstract

To identify antitumor materials, oriental herb extracts were investigated in the present study. The effects of individual oriental herb extracts (OHE) and a mixture of these extracts (MOHE) for antioxidant, free radical scavenging, and tumoricidal activities were determined. The OHEs and MOHE exhibited relatively high free radical scavenging and antioxidant activities, in a concentration dependent manner. The total phenolic contents of the extracts suggest that these compounds may have played a role, at least in part, in the free radical scavenging and antioxidant effects. Since the MOHE showed the highest toxicity against tumor cell lines, the MOHE was administrated in cancer mice models. Consistent with the in vitro studies, the MOHE resulted in prolonged life spans in cancer mice possibly by combination of its anticancer and antioxidant activities. Our data indicate the possibilities of using the MOHE to counteract carcinogenesis as well as other forms of electrophilic toxicity.

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Authors and Affiliations

  1. Department of Food Science and Biotechnology, Sungkyunkwan University, Suwon, Gyeonggi, 440-746, Korea

    Kye Won Park, Su-hyang Ye, So-Ra Jung, Min-hyuk Bang & Ki-Moon Park

  2. Major in Biomodulation, Department of Agricultural Biotechnology, Seoul National University, Seoul, 151-921, Korea

    Young-jun Kim

  3. Department of Biochemistry, College of Life Science and Biotechnology and Laboratory Animal Research Center, Yonsei University, Seoul, 120-749, Korea

    Han-Woong Lee

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  1. Kye Won Park
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  2. Su-hyang Ye
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Correspondence to Ki-Moon Park.

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Park, K.W., Ye, Sh., Kim, Yj. et al. In vitro and in vivo anti-tumor effects of oriental herbal mixtures. Food Sci Biotechnol 19, 1019–1027 (2010). https://doi.org/10.1007/s10068-010-0143-6

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  • DOI: https://doi.org/10.1007/s10068-010-0143-6

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