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Anaplastic large cell lymphoma in a patient with MAGIC syndrome: a case and review of the literature

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Abstract

Mouth and genital ulcer with inflamed cartilage syndrome (MAGIC syndrome) is a rare autoinflammatory disorder with unknown etiology. Except for the common clinical manifestations mimicking Behçet’s disease and relapsing polychondritis, some other clinical entities are occasionally observed. In this report, we present a case in which a patient developed anaplastic large cell lymphoma 1 year after the diagnosis of MAGIC syndrome. Additionally, we review the clinical manifestations, management, and prognosis of MAGIC syndrome.

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Code availability

The figures were created by the GraphPad Prism 8 software.

Funding

This work was supported by the National Natural Science Foundation of China [81871299], the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences [CIFMS 2017-I2M-1-008][CIFMS 2016-I2M-1-013] , National Key Research and Development Program: “Precise Medical Research” [2016YFC0906201].

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Authors and Affiliations

  1. Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Rheumatology, Ministry of Education, National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing, 100730, China

    Zhe Chen, Shangzhu Zhang, Li Wang, Yunyun Fei, Min Shen, Jinjing Liu & Wenjie Zheng

  2. Department of Rheumatology, Beijing Hospital, National Center of Gerontology, Beijing, China

    Zhe Chen

  3. Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China

    Huanwen Wu

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  1. Zhe Chen
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  2. Shangzhu Zhang
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  3. Li Wang
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  4. Yunyun Fei
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  5. Min Shen
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  6. Huanwen Wu
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  7. Jinjing Liu
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  8. Wenjie Zheng
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Contributions

All authors were involved in drafting the article or revising it critically for important intellectual content, and all authors approved the final version to be published. ZC and JL performed the literature researching and summarizing. ZC, SZ, LW, YF, MS, JL, and WZ provided the patient medical care and assistance during the in-hospital period in our department. HW performed the pathological analysis and evaluation. JL and WZ designed this review initially.

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Correspondence to Jinjing Liu or Wenjie Zheng.

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Chen, Z., Zhang, S., Wang, L. et al. Anaplastic large cell lymphoma in a patient with MAGIC syndrome: a case and review of the literature. Clin Rheumatol 40, 2075–2082 (2021). https://doi.org/10.1007/s10067-020-05384-x

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