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Numano type V Takayasu arteritis patients are more prone to have coronary artery involvement

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Abstract

Objectives

Takayasu arteritis (TA) is a rare granulomatous vasculitis. Numano type V was the most frequently involved arteritis in China. In our study, we aimed to investigate the characteristics of the type V TA in Chinese people.

Methods

We retrospectively reviewed 143 medical charts of TA patients who were admitted to Beijing Anzhen Hospital from 2012 to 2019. All statistical studies were carried out with the SPSS program V.24.0.

Results

The duration of disease at first admission of type V TA patients was longer than non-type V group (110.6 (21.0, 168.0) vs. 69.1 (12.0, 120.0) months, P = 0.034). The incidences of hypertension and coronary artery involvement were more common in type V TA patients compared with non-type V patients (59.5% vs. 30.4%, P < 0.001; 33.8% vs. 17.4%, P = 0.025; respectively). The numbers of platelet (PLT) and the plateletcrit (PCT) in type V TA patients were significantly smaller than those in non-type V group (244.9 (190.5, 293.8) vs. 281.6 (214.5, 332.0) × 109/L, P = 0.005; 0.25 (0.20, 0.28) vs. 0.28 (0.22, 0.32) %, P = 0.003; respectively). Lesions located in the left anterior descending coronary (LAD) and the left circumflex coronary (LCX) presented more frequently in type V TA patients than in non-type V patients (LAD 76.0 vs. 41.7%, P = 0.041; LCX 56.0 vs. 8.3%, P = 0.006; respectively).

Conclusions

Type V TA patients had longer disease duration and higher incidence of hypertension and were more prone to have coronary artery involvement compared with non-type V patients.

Key Points

• This study is the first to assess characteristics of the type V TA in Chinese people.

• Type V TA patients had longer disease duration and higher incidence of hypertension and were more prone to have coronary artery involvement compared with non-type V patients.

• The numbers of platelet (PLT) and the plateletcrit (PCT) in type V TA patients were significantly smaller than those in non-type V group.

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Funding

The present study was supported by grants from National Natural Science Foundation of China (91739111, 81900448).

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Authors and Affiliations

  1. Department of Rheumatology, Capital Medical University Affiliated Anzhen Hospital, 2 Anzhen Road, Chaoyang District, Beijing, China

    Taotao Li, Juan Du, Na Gao & Lili Pan

  2. Department of Interventional Radiology, Capital Medical University Affiliated Anzhen Hospital, 2 Anzhen Road, Chaoyang District, Beijing, China

    Xi Guo

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  1. Taotao Li
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  2. Juan Du
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Contributions

Lili Pan contributed to the study conception and design. Material preparation, data collection, and analysis were performed by Taotao Li and Juan Du. Na Gao and Xi Guo performed the statistical analysis. The first draft of the manuscript was written by Taotao Li and all authors commented on previous versions of the manuscript. Lili Pan is the corresponding author of the manuscript who guided the writing and made the corrections of the whole paper. All authors read and approved the final manuscript.

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Correspondence to Lili Pan.

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The study was conducted in accordance with the ethical principles of the Declaration of Helsinki and approved by the Clinical Research Ethics Board of Beijing Anzhen Hospital, Capital Medical University (approval number: 2019020X).

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Li, T., Du, J., Gao, N. et al. Numano type V Takayasu arteritis patients are more prone to have coronary artery involvement. Clin Rheumatol 39, 3439–3447 (2020). https://doi.org/10.1007/s10067-020-05123-2

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