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Metabolic syndrome in psoriatic arthritis: the interplay with cutaneous involvement. Evidences from literature and a recent cross-sectional study

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Abstract

The aim of this study was to evaluate the prevalence of MetS and its components and the level of serum uric acid in patients with PsA and in those with PsA sine psoriasis. A secondary aim of the study was to investigate on correlations of MetS in all study population. Consecutive PsA patients underwent assessment of disease activity and metabolic parameters. Blood samples were collected after 12 h of overnight fasting and analyzed for glucose, lipid profile, serum uric acid, and acute-phase reactants. The NCEP-ACT III criteria were used to identify subjects with MetS. Forty-two patients (52.5%) were classified as having PsA with clinically evident psoriasis (group 1) and 38 (47.5%) as having PsA sine psoriasis (group 2). Group 1, when compared to group 2, showed a significant increase for the frequency of MetS (p = 0.006) and for mean values of diastolic blood pressure (p = 0.0116) and of serum uric acid (p = 0.04). We then aimed at defining determinants of MetS in the entire study population. In the multivariate analysis, three variables reached statistical significance: presence of psoriasis (OR 0.14; p = 0.01), increase of one unit of BMI (OR 1.26; p = 0.001), and smoking habit (OR 5.93; p = 0.02). In our study, the occurrence of MetS and mean levels of serum uric acid were higher in PsA patients with clinical evident psoriasis compared to sine psoriasis PsA. The results also show the potential role of BMI, psoriasis, and smoking as important determinants in the development of MetS in PsA patients.

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Authors and Affiliations

  1. Rheumatology Unit, Department of Clinical Medicine and Surgery, School of Medicine, University Federico II of Naples, via S. Pansini 5, 80131, Naples, Italy

    Francesco Caso, Antonio Del Puente, Rosario Peluso, Nicolò Girolimetto, Paolo Bottiglieri, Francesca Foglia, Carolina Benigno, Marco Tasso, Raffaele Scarpa & Luisa Costa

  2. Rheumatology Unit, Department of Medicine - DIMED, School of Medicine, University of Padova, Via Giustiniani 2, 35128, Padova, Italy

    Francesca Oliviero & Leonardo Punzi

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  1. Francesco Caso
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  2. Antonio Del Puente
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  3. Francesca Oliviero
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Correspondence to Francesco Caso.

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The study was approved by the Local Ethics Committee (CE: NA 126/15) and all patients gave their informed consent.

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Caso, F., Del Puente, A., Oliviero, F. et al. Metabolic syndrome in psoriatic arthritis: the interplay with cutaneous involvement. Evidences from literature and a recent cross-sectional study. Clin Rheumatol 37, 579–586 (2018). https://doi.org/10.1007/s10067-017-3975-0

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