Abstract
To assess the health-related quality of life (HRQOL) of Han Chinese people with systemic lupus erythematosus (SLE) using a Chinese version of the Systemic Lupus Erythematosus-Specific Quality of Life Questionnaire (SLEQOL-C) and explore the factors influencing HRQOL of people with SLE. Participants were Han Chinese people with SLE. The SLEQOL-C and 36-item Short Form Health Survey (SF-36) were used to estimate the HRQOL. Disease activity was determined using the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) and fatigue using the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F). Participant factors included age, gender, educational background, disease duration, erythrocyte sedimentation rate (ESR), and complement C3 and C4 levels. The results showed that higher SLEQQL-C scores correlated with lower SF-36 both measures are essential for HRQQL prediction. The SLEQOL-C scores were correlated with educational level,age, FACIT-F score, SLEDAI score, and ESR, which suggests that poor educational background, old-age, and increased fatigue, disease activity, and ESR might represent poor HRQOL. Although disease duration did not significantly correlate with the scores on the SLEQOL-C; those whose disease duration was 12–24 months had higher SLEQOL-C summary scores and physical functioning, symptoms, and treatment subscale scores than did those whose duration was less than 6 months. The FACIT-F score, education level, age, disease duration, SLEDAI score, and ESR contributed to SLEQOL-C scores. The SLEQOL-C is reliable for assessing HRQOL of Han Chinese people with SLE. Fatigue, educational level, age, disease duration, ESR, and disease activity mainly influenced HRQOL of SLE patients.
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This research was supported by grants from the Education Department of Heilongjiang Province (grant number 12531239).
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Hai-Zhi Jiang, Zhi-Guo Lin, Hong-Juan Li, and Yi-Fang Mei conceived and designed the experiments; Hai-Zhi Jiang, Zhi-Guo Lin, Hong-Juan Li, Qing-Du, Wei-Tian, Shu-Ya Wang, Shang-Qi Guan, and Yi-Fang Mei performed the experiments; Hong-Juan Li and Shu-Ya Wang analyzed the data; Hai-Zhi Jiang and Shu-Ya Wang wrote the paper. Hai-Zhi Jiang and Zhi-Guo Lin contributed equally to this article.
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Jiang, HZ., Lin, ZG., Li, HJ. et al. The Chinese version of the SLEQOL is a reliable assessment of health-related quality of life in Han Chinese patients with systemic lupus erythematosus. Clin Rheumatol 37, 151–160 (2018). https://doi.org/10.1007/s10067-017-3910-4
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DOI: https://doi.org/10.1007/s10067-017-3910-4