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Current concepts and unmet needs in psoriatic arthritis

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Abstract

Psoriatic arthritis is a chronic inflammatory arthritis that is part of the spondyloarthropathy group of rheumatic diseases and has associated co-morbidities. It can present with various clinical manifestations making diagnosis and treatment challenging, resulting in significant disability and reduced quality of life for patients. Whilst there have been advances in understanding the pathogenic mechanisms of the disease which have resulted in targeted therapies, there is still the need for further studies as some patients fail or are intolerant of current therapies. Better identification of early disease and knowledge of prognostic markers would enable clinicians to initiate appropriate therapy with the expectation that early aggressive treatment will minimise joint damage progression. Improved knowledge of the condition would also enable clinicians to better tailor specific treatment strategies for each of the various clinical domains in psoriatic arthritis.

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Authors and Affiliations

  1. Clinical Research Fellow in Rheumatology, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK

    Farrouq Mahmood

  2. Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK

    Laura C Coates

  3. Leeds Institute of Rheumatic & Musculoskeletal Medicine, University of Leeds, Chapel Allerton Hospital, Chapeltown Road, Leeds, LS7 4SA, UK

    Philip S Helliwell

Authors
  1. Farrouq Mahmood
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  2. Laura C Coates
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  3. Philip S Helliwell
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Corresponding author

Correspondence to Philip S Helliwell.

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This paper is not a clinical study and contains no patient data.

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Paper requested by Dr. Luis R Espinoza

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Mahmood, F., Coates, L.C. & Helliwell, P.S. Current concepts and unmet needs in psoriatic arthritis. Clin Rheumatol 37, 297–305 (2018). https://doi.org/10.1007/s10067-017-3908-y

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  • DOI: https://doi.org/10.1007/s10067-017-3908-y

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