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Auditory involvement in Behcet’s disease: relationship with demographic, clinical, and therapeutic characteristics

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Abstract

The study objective was to evaluate the occurrence of sensorineural hearing loss (SNHL) in patients with Behcet’s disease (BD), looking at potential correlations with specific demographic, clinical, and therapeutic features. Forty-four consecutive patients (15 males, 29 females) fulfilling the International Study Group (ISG) and/or the International Criteria for Behçet’s Disease (ICBD) were enrolled. The endpoints of the study consisted in identifying a deflection of at least 25 dB on pure-tone audiometry and performing statistical analysis to evaluate demographic, clinical, or therapeutic differences between patients with and without SNHL. Our patients showed a mean age ± SD of 45.43 ± 14.05 years; a mean age at disease onset ± SD of 31.54 ± 15.53 years; a disease duration ± SD of 13.89 ± 9.15 years. SNHL was highlighted in 28 (63 %) patients representing the fourth most frequent clinical manifestation in our group of patients. Otologic involvement was significantly more frequent among subjects fulfilling ISG criteria than in patients fulfilling ICBD criteria (p = 0.04). Regarding correlations with BD manifestations, SNHL was significantly associated with cutaneous plus articular involvement (p = 0.013). Conversely, detached analysis of articular and skin manifestations led to no significant differences (p = 0.085 and p = 0.067). No further significant correlations were found between SNHL and BD clinical features or previous or concomitant treatments. Hearing loss was the fourth most common clinical feature in our patients and probably represents an underrated aspect of BD. Hearing impairment was significantly associated with cutaneous plus articular involvement, suggesting the importance of an otologic evaluation in such patients.

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Authors and Affiliations

  1. Research Center of Systemic Autoinflammatory Diseases and Behçet’s Disease Clinic, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena, Italy

    Jurgen Sota, Antonio Vitale, Ida Orlando, Mauro Galeazzi, Stefano Gentileschi, Bruno Frediani & Luca Cantarini

  2. Interdisciplinary Department of Medicine, Rheumatology Unit, University of Bari Aldo Moro, Bari, Italy

    Giuseppe Lopalco & Florenzo Iannone

  3. Ophthalmology and Neurosurgery Department, University of Siena, Siena, Italy

    Rossella Franceschini

  4. Department of Ophthalmology, Humanitas Research Hospital, via Alessandro Manzoni 56, Rozzano, 20089, Milan, Italy

    Claudia Fabiani

  5. Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy

    Giacomo Emmi

  6. Rheumatology Unit, Policlinico “Le Scotte”, University of Siena, viale Bracci 1, 53100, Siena, Italy

    Luca Cantarini

Authors
  1. Jurgen Sota
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  2. Antonio Vitale
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  3. Ida Orlando
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  4. Giuseppe Lopalco
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  5. Rossella Franceschini
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  6. Claudia Fabiani
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  7. Mauro Galeazzi
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  8. Giacomo Emmi
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  9. Stefano Gentileschi
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  10. Florenzo Iannone
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  11. Bruno Frediani
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  12. Luca Cantarini
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Corresponding author

Correspondence to Luca Cantarini.

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The local ethics committee approved the study and informed consent was obtained by all participants.

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Sota, J., Vitale, A., Orlando, I. et al. Auditory involvement in Behcet’s disease: relationship with demographic, clinical, and therapeutic characteristics. Clin Rheumatol 36, 445–449 (2017). https://doi.org/10.1007/s10067-016-3367-x

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  • DOI: https://doi.org/10.1007/s10067-016-3367-x

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