Abstract
For the purpose of investigating Behcet’s disease (BD) in Russia, 250 consecutive patients (177 men and 73 women) diagnosed with BD between 1990 and 2010 at the Research Institute of Rheumatology, Russian Academy of Medical Sciences in Moscow were enrolled in this study. The ethnic backgrounds of the patients were reported as follows: 23.2 % (58 cases) from Russia, 12.8 % (32 cases) from Azerbaijan, 14.4 % (36 cases) from Armenia, 8.8 % (22 cases) from Chechnya, and 21.6 % (55 cases) from Dagestan. The remaining 19.2 % (48 cases) were from other regions or of unknown origin. More than half (57.6 %) of the Behcet’s disease patients originated from Central Asia, specifically Azerbaijan, Armenia, Chechnya, and Dagestan. The mean age at disease onset was 31.5 ± 9.38 (13–60) years old, and the most typical initial manifestations were oral aphthous ulcers. Patients aged 20–39 years old were more commonly affected and displayed a wide clinical spectrum of the disease, with varieties of severe internal organ involvement. The manifestations observed throughout the course of the disease included oral aphthous ulcers (100 %), various cutaneous lesions (88.8 %), genital ulcers (81.2 %), and ocular lesions (54.0 %). Besides these, many organs/systems were implicated in patient cases, namely joint (53.2 %), vascular (25.2 %), neurological (8.0 %), gastrointestinal (25.2 %), and cardiac (5.6 %) systems. Involvements of ocular (p < 0.01) and skin (p < 0.01) lesions were more frequent in men than in women. HLA-B51 and HLA-A26 typing was performed in 127 patients and 508 healthy controls. HLA-B51 was found in 63.0 % of BD patients compared to 20.7 % of the healthy control subjects (p < 0.001), and HLA-A26 was present in 11.3 % of BD patients and 18.9 % of the control group. This study shows the presence of BD in Russia, and it is suggested that its prevalence in Central Asian people is much higher than that in White Russian.
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References
International Study Group for Behcet’s disease (1990) Criteria for diagnosis of Behcet’s disease. Lancet 335(8697):1078-80
Azizlerli G, Kose AA, Sarica R, Gul A, Tutkun IT, Kulac M et al (2003) Prevalence of Behcet’s disease in Istanbul, Turkey. Int J Dermatol 42(10):803–806
Bang D, Yoon KH, Chung HG, Choi EH, Lee ES, Lee S (1997) Epidemiological and clinical features of Behcet’s disease in Korea. Yonsei Med J 38(6):428–436
Barkhudaryan S (1969) The Armenian-Caucasian Albanian Kingdom of Derbend. Patma-Banasirakan Handes 3:125–147
Davatchi F, Shahram F, Chams-Davatchi C, Shams H, Nadji A, Akhlaghi M et al (2010) Behcet’s disease in Iran: analysis of 6500 cases. Int J Rheum Dis 13(4):367–373
El Menyawi MM, Raslan HM, Edrees A (2009) Clinical features of Behcet’s disease in Egypt. Rheumatol Int 29(6):641–646
Horie Y, Meguro A, Kitaichi N, Lee EB, Kanda A, Noda K et al (2012) Replication of a microsatellite genome-wide association study of Behcet’s disease in a Korean population. Rheumatology (Oxford) 51(6):983–986
Horie Y, Meguro A, Ota M, Kitaichi N, Katsuyama Y, Takemoto Y et al (2009) Association of TLR4 polymorphisms with Behcet’s disease in a Korean population. Rheumatology (Oxford) 48(6):638–642
Ideguchi H, Suda A, Takeno M, Ueda A, Ohno S, Ishigatsubo Y (2011) Behcet disease: evolution of clinical manifestations. Medicine (Baltimore) 90(2):125–132
Kaneko F, Nakamura K, Sato M, Tojo M, Zheng X, Zhang JZ (2003) Epidemiology of Behcet’s disease in Asian countries and Japan. Adv Exp Med Biol 528:25–29
Kaya TI (2012) Genetics of Behcet’s Disease. Patholog Res Int 2012:912589
Kaya TI, Dur H, Tursen U, Gurler A (2002) Association of class I HLA antigens with the clinical manifestations of Turkish patients with Behcet’s disease. Clin Exp Dermatol 27(6):498–501
Kitaichi N, Miyazaki A, Iwata D, Ohno S, Stanford MR, Chams H (2007) Ocular features of Behcet’s disease: an international collaborative study. Br J Ophthalmol 91(12):1579–1582
Kitaichi N, Miyazaki A, Stanford MR, Iwata D, Chams H, Ohno S (2009) Low prevalence of juvenile-onset Behcet’s disease with uveitis in East/South Asian people. Br J Ophthalmol 93(11):1428–1430
Krause I, Molad Y, Weinberger A (1999) Association of HLA-B5 with clinical expression and severity of Behcet’s disease in Israel. J Clin Rheumatol 5(3):137–140
Meguro A, Inoko H, Ota M, Katsuyama Y, Oka A, Okada E et al (2010) Genetics of Behcet disease inside and outside the MHC. Ann Rheum Dis 69(4):747–754
Mizuki N, Meguro A, Ota M, Ohno S, Shiota T, Kawagoe T et al (2010) Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behcet’s disease susceptibility loci. Nat Genet 42(8):703–706
Neves FS, Caldas CA, Lage LV, Goldenstein-Schainberg C, Goncalves CR (2009) Faraway from the silk route: demographic and clinical features of Behcet’s disease in 106 Brazilian patients. Clin Rheumatol 28(5):543–546
Ohno S, Aoki K, Sugiura S, Nakayama E, Itakura K (1973) Letter: HL-A5 and Behcet’s disease. Lancet 2(7842):1383–1384
Ohno S, Ohguchi M, Hirose S, Matsuda H, Wakisaka A, Aizawa M (1982) Close association of HLA-Bw51 with Behcet’s disease. Arch Ophthalmol 100(9):1455–1458
Remmers EF, Cosan F, Kirino Y, Ombrello MJ, Abaci N, Satorius C et al (2010) Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behcet’s disease. Nat Genet 42(8):698–702
Sachetto Z, Mahayri N, Ferraz RH, Costallat LT, Bertolo MB (2011) Behcet’s disease in Brazilian patients: demographic and clinical features. Rheumatol Int 32(7):2063–2067
Sakane T, Takeno M, Suzuki N, Inaba G (1999) Behcet’s disease. N Engl J Med 341(17):1284–1291
Verity DH, Marr JE, Ohno S, Wallace GR, Stanford MR (1999) Behcet’s disease, the Silk Road and HLA-B51: historical and geographical perspectives. Tissue Antigens 54(3):213–220
Zhang Z, He F, Shi Y (2012) Behcet’s disease seen in China: analysis of 334 cases. Rheumatol Int 33(3):645–648
Acknowledgments
This work was supported by grants from the Japan Society for the Promotion of Science (JSPS) KAKENHI (grant numbers: 25462731, 23592602, and 22133010) and Russian Academy of Medical Science (RAMS) as part of study on Behcet’s disease in Russia.
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Anton Lennikov and Zemfira Alekberova contributed equally to this work.
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Lennikov, A., Alekberova, Z., Goloeva, R. et al. Single center study on ethnic and clinical features of Behcet’s disease in Moscow, Russia. Clin Rheumatol 34, 321–327 (2015). https://doi.org/10.1007/s10067-013-2442-9
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DOI: https://doi.org/10.1007/s10067-013-2442-9