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Flexion contractures in secondary adrenal insufficiency

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Abstract

We report the case of a 55-year-old male with flexion contractures of the hips and the knees due to an isolated adrenocorticotropin (ACTH) deficiency, a rare cause of secondary adrenal insufficiency. The presenting symptoms and signs, the laboratory investigations and the treatment are described. The case description is followed by a brief overview of ACTH deficiency and its symptoms and causes. Our case is then compared with other case reports available in the literature. The aetiology of the flexion contractures in adrenal insufficiency is still unclear. The authors want to draw attention to adrenal insufficiency as the cause of unexplained flexion contractures.

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References

  1. Andrioli M, Pecori Giraldi F, Cavagnini F (2006) Isolated corticotrophin deficiency. Pituitary 9(4):289–295. doi:10.1007/s11102-006-0408-5

    Article  CAS  PubMed  Google Scholar 

  2. Biller B, Daniels G (1998) Neuroendocrine regulation and diseases of the anterior pituitary and hypothalamus. In: Braunwald, Isselbacher, Wilson, Kasper, Hauser, Longo, Fauci (eds) Harrison’s principles of internal medicine, 14th edn. McGraw-Hill, New York, p 1987

    Google Scholar 

  3. Ebinger G, Six R, Bruyland M, Somers G (1986) Flexion contractures: a forgotten symptom in Addison’s disease and hypopituitarism. Lancet 2(8511):858. doi:10.1016/s0140-6736(86)92887-4

    Article  CAS  PubMed  Google Scholar 

  4. Shapiro M, Trebich C, Shilo L, Shenkman L (1988) Myalgias and muscle contractures as the presenting sign of Addison’s disease. Postgrad Med J 64(749):222–223

    Article  CAS  PubMed  Google Scholar 

  5. Yabuki S, Shiomi F (1984) Syndrome of “contracture facio-brachio-abdomino-crurale en flexion” in a case of isolated ACTH deficiency. Rinsho Shinkeigaku 24(7):729–735

    CAS  PubMed  Google Scholar 

  6. Nakamagoe K, Ohkoshi N, Ishii A, Oguni E, Mizusawa H (1994) Syndrome of contracture facio-brachio-abdomino-crurale en flexion in a case of isolated ACTH deficiency-biopsy findings of muscle and nerve. Rinsho Shinkeigaku 34(3):250–254

    CAS  PubMed  Google Scholar 

  7. Odagaki T, Noguchi Y, Fukui T (2003) Flexion contractures of the legs as the initial manifestation of adrenocortical insufficiency. Intern Med 42(8):710–713

    Article  PubMed  Google Scholar 

  8. Syriou V, Moisidis A, Tamouridis N, Alexandraki K, Anapliotou M (2008) Isolated adrenocorticotropin deficiency and flexion contractures syndrome. Hormones 7(4):320–324

    PubMed  Google Scholar 

  9. Blandford R, Samanta A, Burden A, Rosenthal F (1985) Muscle contractures associated with glucocorticoid deficiency. British Medical Journal 291(6488):127–128

    Article  CAS  PubMed  Google Scholar 

  10. Nishikawa T (2003) Editorial: flexion contractures possibly reflect the existence of hypocortisolism. Intern Med 42(8):629–631

    Article  PubMed  Google Scholar 

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Correspondence to Rudi Chappel.

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Berger, J., Herregods, P., Verhelst, J. et al. Flexion contractures in secondary adrenal insufficiency. Clin Rheumatol 29, 115–117 (2010). https://doi.org/10.1007/s10067-009-1289-6

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