Abstract
Treatment of rheumatoid arthritis (RA) is monitored with the disease activity score (DAS28), for which the erythrocyte sedimentation rate (ESR) is needed. Apart from the original gold standard method, other methods like the Alifax Test-1TH apparatus are widely used in laboratory worldwide. We compared ESR values obtained by the Alifax Test-1Th apparatus and the gold standard method for 218 RA patients. We found a good correlation (r = 0.87) between the Alifax Test-1TH results and the gold standard method. A good correlation (r = 0.96) was also found for the DAS28 results obtained with both methods. The number of patients that were misclassified when the Alifax Test-1TH is used is reasonable for both the ESR (14.7%) and the DAS28 (10.6%). These results suggest that it may be useful to determine the ESR by the Alifax Test-1TH, with a DAS28 misclassification in less than 11% of the patients.
References
Van der Heijde DM, van’t Hof MA, van Riel PL, Theunisse LA, Lubberts EW, van Leeuwen MA, van Rijswijk MH, van de Putte LB (1990) Judging disease activity in clinical practice in rheumatoid arthritis. First step in the development of a disease activity score. Ann Reum Dis 49:916–920
Van der Heijde DM, van’t Hof MA, van Riel PL, van de Putte LB (1993) Development of a disease activity score based on judgment in clinical practice by rheumatologists. J Rheumatol 20(3):579–581
Pincus T, Sokka T (2005) Complexities in the quatitative assessment of patients with rheumatic diseases in clinical trials and clinical care. Clin Exp Rheumatol 23:S1–S9
Fransen J, van Riel PLCM (2006) Das remission cut points. Clin Exp Rheumatol 24:S29–S32
Grigor C, Capell H, Stirling A, McMahon AD, Lock P, Vallance R, Kincaid W, Porter D (2004) Effect of a strategy for tight control of rheumatoid arthritis (the TICORA study): a single-blind randomised controlled trial. Lancet 364:263–269
Prevoo MML, van Gestel AM, van’t Hof MA, van Rijswijk MH, van de Putte LBA, van Riel PCLM (1996) Remission in a prospective study of patients with rheumatoid arthritis. American Rheumatism Association preliminary remission criteria in relation to the disease activity score. Br J Rheumatol 35:1101–1105
Westergren A (1921) Studies of the suspension stability of the blood pulmonary tuberculosis. Acta Med Scand 46:198–203
Passing H, Bablok W (1983) A new biometrical procedure for testing the equality of measurements from two different analytical methods. Application of linear regression procedures for method comparison studies in clinical chemistry, Part I. J Clin Chem Clin Biochem 21(11):709–720
Passing H, Bablok W (1984) Comparison of several regression procedures for method comparison studies and determination of sample sizes. Application of linear regression procedures for method comparison studies in Clinical Chemistry, Part II. J Clin Chem Clin Biochem 22(6):431–445
Bland JM, Altman DG (1986) Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1(8476):307–310
Ledingham J, Deighton C, on behalf of the British Society for Rheumatology Standards GaAWG (SGAWG) (2005) Update on the British Society for Rheumatology guidelines for prescribing TNFalpha blockers in adults with rheumatoid arthritis (update of previous guidelines of April 2001). Rheumatology 44:157–163
Fransen J, Creemers MCW, van Riel PCLM (2004) Remission in reumatoid arthritis: agreement of the disease activity score (DAS28) with the ARA preliminary remission criteria. Rheumatology 43(10):1252–1255
Oosting JD, Pel V, Groenevelt R, Sant van’t P (2003) Karakterisering van de bepaling van de bezinkingssnelheid van erytrocyten met behulp van de Test-1 van Alifax. Ned Tijdschr Klin Chem 28:197–198
De jonge N, Sewkaransing I, Slinger J, Rijsdijk JJM (2000) Erythrocyte sedimentation by the Test-1 analyzer. Clin Chem 46:881–882
Plebani M, Piva E (2002) Erythrocyte sedimentation rate: use of fresh blood for quality control. Am J Clin Pathol 117(4):621–626
Acknowledgements
The authors would like to thank Lisanne Mirck-Jansen Duighuizen for excellent technical assistance and the research assistants at the Jan van Breemen Institute for assisting in the data collection.
Declaration of competing interests
The authors state not to have any competing interests.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Levitus, M., Pelliccia, A., van de Stadt, R.J. et al. Is the Alifax Test-1TH useful to determine the Disease Activity Score (DAS28) in rheumatoid arthritis patients?. Clin Rheumatol 28, 469–474 (2009). https://doi.org/10.1007/s10067-009-1092-4
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10067-009-1092-4