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High sensitivity C-reactive protein and endothelial function in Chilean patients with history of Kawasaki disease

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Abstract

Kawasaki disease (KD) produces endothelial inflammation, which may lead to dilatation and aneurysms of coronary and peripheral arteries. Previous studies have suggested that these patients can present endothelial dysfunction that can predispose to coronary vascular events late after KD. The purpose of this study was to determine the cardiovascular risk profile and endothelial function of Chilean children with history of KD. In a prospective case-control study, 11 patients with history of KD (age 10.6 ± 2.0 years, interval from initial episode 8.1 ± 3.6 years) and 11 healthy, age-, gender-, and BMI z score-matched controls were evaluated with blood pressure (BP), a fasting lipid profile, high sensitivity C-reactive protein (hsCRP), and flow-mediated dilatation of the brachial artery (FMD). One KD patient (9.1%) had persistent coronary aneurysms. There was a significant difference of mean and log-transformed concentrations of hsCRP between case and control groups (2.3 ± 3.0 vs 0.5 ± 0.3 mg/l, P = 0.045). None of the patients with elevated hsCRP had persistent coronary arterial lesions. No difference was found in systolic BP z score between the case and control groups. Diastolic BP z score was significantly higher in cases than controls (P = 0.039). There were no significant differences of FMD between cases and controls. Mean fasting total cholesterol, high-density and low-density lipoprotein, and triglycerides in cases were normal, with no significant difference vs controls. This study shows that Chilean children with history of KD have increased levels of hsCRP, possibly reflecting persistent low-grade inflammation. The prognostic value of hsCRP in KD patients deserves further investigation.

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Acknowledgments

This study was funded by a Resident Project Grant PG29-05 of the Pontificia Universidad Católica de Chile School of Medicine.

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Authors and Affiliations

  1. Department of Pediatrics, Pontificia Universidad Católica de Chile School of Medicine, Lira 85, 5to piso, Santiago, Chile

    Arturo Borzutzky, Eduardo Talesnik & Pilar Arnaiz

  2. Department of Rheumatology, Pontificia Universidad Católica de Chile School of Medicine, Santiago, Chile

    Miguel Gutiérrez & Eduardo Talesnik

  3. Department of Cardiovascular Diseases, Pontificia Universidad Católica de Chile School of Medicine, Santiago, Chile

    Iván Godoy, Pilar Arnaiz & Mónica Acevedo

  4. Pontificia Universidad Católica de Chile School of Medicine, Santiago, Chile

    Jonathan Kraus & Rodrigo Hoyos

Authors
  1. Arturo Borzutzky
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  2. Miguel Gutiérrez
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  3. Eduardo Talesnik
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  4. Iván Godoy
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  5. Jonathan Kraus
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  6. Rodrigo Hoyos
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  7. Pilar Arnaiz
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  8. Mónica Acevedo
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Correspondence to Arturo Borzutzky.

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Borzutzky, A., Gutiérrez, M., Talesnik, E. et al. High sensitivity C-reactive protein and endothelial function in Chilean patients with history of Kawasaki disease. Clin Rheumatol 27, 845–850 (2008). https://doi.org/10.1007/s10067-007-0808-6

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  • DOI: https://doi.org/10.1007/s10067-007-0808-6

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