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Morphological characteristics in peritoneum in patients with neutral peritoneal dialysis solution

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  • Artificial Kidney / Dialysis
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Abstract

Peritoneal dialysis solution (PDS) plays a role in functional and morphological damage to the peritoneum. This study aimed to clarify the effect of neutral PDS in preventing morphological changes by assessing peritoneal damage and comparing morphological alterations between PD patients treated with neutral PDS and acidic PDS. Sixty-one patients participated from seven hospitals. All patients were treated with neutral PDS excluding icodextrin, during their entire PD treatment, and experienced no episode of peritonitis. The thickness of submesothelial compact (SMC) zone and the presence of vasculopathy in the anterior parietal abdominal peritoneum were assessed. The impact of icodextrin, hybrid therapy, and peritoneal rest and lavage in morphological alterations were determined. There was no significant difference in the average SMC thickness between neutral and acidic PDS. The vessel patency in patients using neutral PDS was significantly higher compared to that in acidic PDS at any time during PD. There were no significant suppressive effects from interventions or use of icodextrin with respect to peritoneal morphological injury. A monolayer of mesothelial cell was observed in approximately half the patients, especially in their receiving lavage patients. Neutral PDS, accompanied by other preventive approaches against peritoneal injury, might suppress the development of peritoneal morphological alterations.

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Conflict of interest

The authors have no conflicts of interest to declare expect Dr. Yasuhiko Ito. He is a professor in endowed chair supported by Baxter Japan.

Author information

Authors and Affiliations

  1. Division of Nephrology, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, Japan

    Chieko Hamada & Hirotaka Nakamoto

  2. Department of Pathology, Tokyo Women’s Medical University, Tokyo, Japan

    Kazuho Honda

  3. Department of Medicine Kidney Center, Tokyo Women’s Medical University, Tokyo, Japan

    Kunio Kawanishi

  4. Department of Nephrology, Nagoya University Graduate School of Medicine, Tokyo, Japan

    Yasuhiko Ito

  5. Division of Nephrology and Hypertension, St. Marianna University School of Medicine, Tokyo, Japan

    Tsutomu Sakurada

  6. Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan

    Yudo Tanno

  7. Nephrology and Dialysis Center, Fukuoka Red-Cross Hospital, Tokyo, Japan

    Toru Mizumasa

  8. Miyazaki Clinic, Tokyo, Japan

    Masanobu Miyazaki

  9. Tsuchiya General Hospital, Tokyo, Japan

    Misaki Moriishi

  10. Department of Nephrology, Fukushima Medical University School of Medicine, Tokyo, Japan

    Masaaki Nakayama

Authors
  1. Chieko Hamada
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  2. Kazuho Honda
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  3. Kunio Kawanishi
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  4. Hirotaka Nakamoto
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  5. Yasuhiko Ito
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  6. Tsutomu Sakurada
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  7. Yudo Tanno
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  8. Toru Mizumasa
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  9. Masanobu Miyazaki
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  10. Misaki Moriishi
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  11. Masaaki Nakayama
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Corresponding author

Correspondence to Chieko Hamada.

Additional information

On behalf of the Peritoneal Biopsy Study Group of the Japanese Society for Peritoneal Dialysis.

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Hamada, C., Honda, K., Kawanishi, K. et al. Morphological characteristics in peritoneum in patients with neutral peritoneal dialysis solution. J Artif Organs 18, 243–250 (2015). https://doi.org/10.1007/s10047-015-0822-4

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  • DOI: https://doi.org/10.1007/s10047-015-0822-4

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