Skip to main content
SpringerLink
Log in

Longer storage of dialyzers increases elution of poly(N-vinyl-2-pyrrolidone) from polysulfone-group dialysis membranes

  • Original Article
  • Published:
Journal of Artificial Organs Aims and scope Submit manuscript

Abstract

The objective of this study was to evaluate the effect of protracted storage of dialyzers on the amount of poly(N-vinyl-2-pyrrolidone) (PVP) eluted from polysulfone-group dialysis membranes. We tested five dialysis membranes: APS-15SA (Asahi Kasei Kuraray, wet), CX-1.6U (Toray, moist), FX140 (Fresenius, dry), PES-15Sα (Nipro, dry), and FDX-150GW (Nikkiso, wet). Each dialyzer was stored for 1, 3, 14, and 18 months after sterilization. The dialysis-fluid side compartment was primed with reverse osmosis (RO) water at 500 mL/min for 5 min at 310 K. The blood side compartment was primed with RO water at 200 mL/min for 5 min at 310 K. Finally, 1 L RO water was circulated through the blood side compartment at 200 mL/min for 4 h at 310 K. Eluted PVP was determined by use of the iodine method, using 0.02 N iodine solution. PVP was mainly eluted from wet-type dialyzers during priming. Thus, the standard 5 min priming of the wet-type dialyzer according to the maker manual inhibits PVP elution during circulation. PVP was eluted in the dialysis-fluid side of the moist-type dialyzer during priming but no PVP was eluted in the blood side. PVP was mainly eluted from dry-type dialyzers during circulation. We recommend more than the standard 5 min priming, particularly for dry-type dialyzers stored for protracted periods, because 5 min insufficient to inhibit PVP elution during circulation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Frank HP. The lactam-amino acid equilibria for ethylpyrrolidone and polyvinylpyrrolidone. Polym J Sci. 1954;12:565–76.

    Article  CAS  Google Scholar 

  2. Doneux C, Caudano R. Polymerization of N-vinyl-2-pyrrolidone under anodic polarization: characterization of the modified electrode and study of the grafting mechanism. Langmuir. 1997;13:4898–905.

    Article  CAS  Google Scholar 

  3. Pert JH, Moore R, Schork PK. Review of studies in blood freezing using glucose-lactose and polyvinylpyrrolidone methods. National research council: conference on long-term preservation of red blood cells; 1965.

  4. Koshikawa S. Transfusion. Tokyo: Chugai Iyakusha; 1960, p. 173–87 (in Japanese).

  5. Arakawa M, Suzuki S. Withdrawal of PVP drug. Nihon Iji Shinpo 1965;3375:126 (in Japanese).

    Google Scholar 

  6. Streicher E, Schneider H. Polysulfone membrane mimicking human glomerular basement membrane. Lancet. 1983;2:1136.

    Article  PubMed  CAS  Google Scholar 

  7. Ochoa NA, Pradanos P, Palacio L, Pagliero C, Marchese J, Hernández A. Pore size distributions based on AFM imaging and retention of multidisperse polymer solutes: characterisation of polyethersulfone UF membranes with dopes containing different PVP. J Membr Sci. 2001;187:227–37.

    Article  CAS  Google Scholar 

  8. Matsuda M, Yamamoto K, Yakushiji T, Fukuda M, Miyasaka T, Sakai K. Nanotechnological evaluation of protein adsorption on dialysis membrane surface hydrophilized with polyvinylpyrrolidone. J Membr Sci. 2008;310:219–28.

    Article  CAS  Google Scholar 

  9. Namekawa K, Fukuda M, Matsuda M, Yagi Y, Yamamoto K, Sakai K. Nanotechnological characterization of human serum albumin adsorption on wet synthetic polymer dialysis membrane surfaces. ASAIO J. 2009;55:236–42.

    Article  PubMed  CAS  Google Scholar 

  10. Hayama M, Yamamoto K, Kohori F, Uesaka T, Ueno Y, Sugaya H, Itagaki I, Sakai K. Nanoscopic behavior of polyvinylpyrrolidone particles on polysulfone/polyvinylpyrrolidone film. Biomaterials. 2004;25:1019–28.

    Article  PubMed  CAS  Google Scholar 

  11. Hayama M, Yamamoto K, Kohori F, Sakai K. How polysulfone dialysis membranes containing polyvinylpyrrolidone achieve excellent biocompatibility? J Membr Sci. 2004;234:41–9.

    Article  CAS  Google Scholar 

  12. Matsuda M, Sato M, Sakata H, Ogawa T, Yamamoto K, Yakushiji T, Fukuda M, Miyasaka T, Sakai K. Effects of fluid flow on elution of hydrophilic modifier from dialysis membrane surfaces. J Artif Organs. 2008;11:148–55.

    Article  PubMed  CAS  Google Scholar 

  13. Müller K. Detection and determination of polyvinylpyrrolidone (PVP) and determination of active components in PVP-containing drug preparations. Pharm Acta Helv. 1968;43:107–22 (in German).

    Google Scholar 

  14. Trimpin S, Eichhorn P, Räder HJ, Müllen K, Knepper TP. Recalcitrance of poly(vinylpyrrolidone): evidence through matrixassisted laser desorption–ionization time-of-flight mass spectrometry. J Chromatogr A. 2001;938:67–77.

    Article  PubMed  CAS  Google Scholar 

  15. Benamer S, Mahlous M, Boukrif A, Mansouri B, Larbi Youssef S. Synthesis and characterisation of hydrogels based on poly(vinyl pyrrolidone). Nucl Instrum Methods Phys B. 2006;248:284–90.

    Article  CAS  Google Scholar 

  16. Davis EJ, Senogles E. γ-Irradiation of N-vinylpyrrolidin-2-one and its homopolymer. Aust J Chem. 1981;34:1413–21.

    Article  CAS  Google Scholar 

  17. Peniche C, Zaldivar D, Pazos M, Paz S, Bulay A, San Roman J. Study of the thermal degradation of poly(N-vinyl-2-pyrrolidone) by thermogravimetry-FTIR. J Appl Polym Sci. 1993;50:485–93.

    Article  CAS  Google Scholar 

  18. Hassouna F, Therias S, Mailhot G, Gardette JL. Photooxidation of poly(N-vinylpyrrolidone) (PVP) in the solid state and in aqueous solution. Polym Degrad Stab. 2009;94:2257–66.

    Article  CAS  Google Scholar 

Download references

Acknowledgments

This work was carried out in the Global COE program “Center for Practical Chemical Wisdom” and the Encouraging Development Strategic Research Centers Program (Super COE) “Establishment of a Consolidated Research Institute for Advanced Science and Medical Care” from the Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT).

Author information

Authors and Affiliations

  1. Sakai Laboratory, Department of Chemical Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo, 169-8555, Japan

    Koki Namekawa, Ami Kaneko, Kiyotaka Sakai, Satoru Kunikata & Masato Matsuda

Authors
  1. Koki Namekawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ami Kaneko
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kiyotaka Sakai
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Satoru Kunikata
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Masato Matsuda
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Koki Namekawa or Kiyotaka Sakai.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Namekawa, K., Kaneko, A., Sakai, K. et al. Longer storage of dialyzers increases elution of poly(N-vinyl-2-pyrrolidone) from polysulfone-group dialysis membranes. J Artif Organs 14, 52–57 (2011). https://doi.org/10.1007/s10047-011-0552-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10047-011-0552-1

Keywords

Search

Navigation