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Restoration of albumin production by nucleoside analogue therapy in patients with chronic hepatitis B

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Abstract

The clinical course of patients with chronic hepatitis B (CH-B) was greatly changed by the introduction of nucleoside analogues. We often encounter patients where the serum level of albumin recovers quickly following the treatment. In this study, we focused carefully on the changes in serum albumin level noted during nucleoside analogue therapy, in an effort to clarify the mechanism behind the restoration of albumin production. We observed changes in serum albumin levels during nucleoside analogue therapy in 12 patients with CH-B and studied the mechanism behind the restoration of albumin production following the therapy. The serum level of albumin was significantly increased very soon after the treatment was started. Prior to treatment with nucleoside analogues, the albumin signal for mRNA was only slightly seen in the peri-portal area, whereas 12 months after the treatment, the liver tissue presented an obvious signal of albumin mRNA. Serum levels of hepatocyte growth factor (HGF) were significantly decreased 12 months after the treatment. In this study, we demonstrated that nucleoside analogues decrease HGF through the suppression of hepatocyte damage, leading to the restoration of albumin production in patients with CH-B.

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References

  1. Liaw YF, Chu CM (2009) Hepatitis B virus infection. Lancet 373:582–592

    Article  CAS  PubMed  Google Scholar 

  2. Hadziyannis SJ (2007) Treatment paradigms on hepatitis B e antigen-negative chronic hepatitis B patients. Expert Opin Investig Drugs 16:777–786

    Article  CAS  PubMed  Google Scholar 

  3. Dienstag JL, Goldin RD, Heathcote EJ, Hann HW, Woessner M, Stephenson SL, Gardner S, Gray DF, Schiff ER (2003) Histological outcome during long-term lamivudine therapy. Gastroenterology 124:105–117

    Article  CAS  PubMed  Google Scholar 

  4. Dugaiczyk A, Law SW, Dennison OE (1982) Nucleotide sequence and the encoded amino acids of human serum albumin mRNA. Proc Natl Acad Sci USA 79:71–75

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  5. Krishna M, Lloyd RV, Batts KP (1997) Detection of albumin messenger RNA in hepatic and extrahepatic neoplasms. A marker of hepatocellular differentiation. Am J Surg Pathol 21:147–152

    Article  CAS  PubMed  Google Scholar 

  6. Yuen MF, Chow DH, Tsui K, Wong BC, Yuen JC, Wong DK, Lai CL (2005) Liver histology of Asian patients with chronic hepatitis B on prolonged lamivudine therapy. Aliment Pharmacol Ther 21:841–849

    Article  CAS  PubMed  Google Scholar 

  7. Chang TT, Liaw YF, Wu SS, Schiff E, Han KH, Lai CL, Safadi R, Lee SS, Halota W, Goodman Z, Chi YC, Zhang H, Hindes R, Iloeje U, Beebe S, Kreter B (2010) Long-term entecavir therapy results in the reversal of fibrosis/cirrhosis and continued histological improvement in patients with chronic hepatitis B. Hepatology 52:886–893

    Article  CAS  PubMed  Google Scholar 

  8. Huang Y, Shinzawa H, Togashi H, Takahashi T, Kuzumaki T, Otsu K, Ishikawa K (1995) Interleukin-6 down-regulates expressions of the aldolase B and albumin genes through a pathway involving the activation of tyrosine kinase. Arch Biochem Biophys 320:203–209

    Article  CAS  PubMed  Google Scholar 

  9. Guillen MI, Gomez-Lechon MJ, Nakamura T, Castell JV (1996) The hepatocyte growth factor regulates the synthesis of acute-phase proteins in human hepatocytes: divergent effect on interleukin-6-stimulated genes. Hepatology 23:1345–1352

    Article  CAS  PubMed  Google Scholar 

  10. Yamaoka M, Hirata K, Ogata I, Tomiya T, Nagoshi S, Mochida S, Fujiwara K (1998) Enhancement of albumin production by hepatocyte growth factor in rat hepatocytes: distinction in mode of action from stimulation of DNA synthesis. Liver 18:52–59

    Article  CAS  PubMed  Google Scholar 

  11. Takehara T, Matsumoto K, Nakamura T (1992) Cell density-dependent regulation of albumin synthesis and DNA synthesis in rat hepatocytes by hepatocyte growth factor. J Biochem 112:330–334

    CAS  PubMed  Google Scholar 

  12. Beauchamp RD, Sheng HM, Ishizuka J, Townsend CM Jr, Thompson JC (1992) Transforming growth factor (TGF)-beta stimulates hepatic jun-B and fos-B proto-oncogenes and decreases albumin mRNA. Ann Surg 216:300–307 (discussion 307–308)

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  13. Mackiewicz A, Ganapathi MK, Schultz D, Brabenec A, Weinstein J, Kelley MF, Kushner I (1990) Transforming growth factor beta 1 regulates production of acute-phase proteins. Proc Natl Acad Sci USA 87:1491–1495

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  14. Flisiak R, Al-Kadasi H, Jaroszewicz J, Prokopowicz D, Flisiak I (2004) Effect of lamivudine treatment on plasma levels of transforming growth factor beta1, tissue inhibitor of metalloproteinases-1 and metalloproteinase-1 in patients with chronic hepatitis B. World J Gastroenterol 10:2661–2665

    CAS  PubMed  Google Scholar 

  15. Murray GI, Paterson PJ, Ewen SW, Melvin WT (1992) In situ hybridisation of albumin mRNA in normal liver and hepatocellular carcinoma with a digoxigenin labelled oligonucleotide probe. J Clin Pathol 45:21–24

    Article  CAS  PubMed Central  PubMed  Google Scholar 

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Acknowledgments

A part of this study was supported by the Japan Society for the Promotion of Science (JSPS).

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Authors and Affiliations

  1. Department of Infectomics and Molecular Pathogenesis, Center for Research and Advanced Studies, National Polytechnic Institute, Mexico City, Mexico

    Mineko Shibayama

  2. Department of Cell Biology, Center for Research and Advanced Studies, National Polytechnic Institute, Mexico City, Mexico

    Jesus Serrano-Luna

  3. Department of Gastroenterology, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 8140108, Japan

    Tetsuro Sohda, Motoko Kawashima, Eri Yamauchi, Takashi Tanaka, Shu-ichi Ueda, Daisuke Morihara, Akira Anan, Yasuaki Takeyama, Makoto Irie, Kaoru Iwata, Satoshi Shakado & Shotaro Sakisaka

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  1. Mineko Shibayama
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  2. Jesus Serrano-Luna
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  3. Tetsuro Sohda
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  4. Motoko Kawashima
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  11. Makoto Irie
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Correspondence to Tetsuro Sohda.

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Shibayama, M., Serrano-Luna, J., Sohda, T. et al. Restoration of albumin production by nucleoside analogue therapy in patients with chronic hepatitis B. Med Mol Morphol 47, 207–212 (2014). https://doi.org/10.1007/s00795-013-0065-5

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  • DOI: https://doi.org/10.1007/s00795-013-0065-5

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