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Sexually transmitted infections among adolescents with conduct disorder: a nationwide longitudinal study

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Abstract

Studies have demonstrated that conduct disorder is related to risky sexual behaviors, the dominant risk factor for contracting a sexually transmitted infection (STI). However, the association between conduct disorder and STIs remains unclear. Using the Taiwan National Health Insurance Research Database, 5733 adolescents with conduct disorder and 22,932 age- and sex-matched controls without conduct disorder were enrolled from 2001 to 2009 and were subject to follow-up until the end of 2011. Participants who contracted any STI during the follow-up period were identified. Cox regression analysis was performed to examine the likelihood of subsequently contracting an STI for patients and controls. Patients with conduct disorder were more likely than controls to develop any STI (HR 3.95, 95% CI 2.97–5.26) after adjusting for demographic data, psychiatric comorbidities, and use of medications. Long-term use of second-generation antipsychotics (SGAs) was related to a reduced risk (HR 0.36, 95% CI 0.14–0.91) of developing an STI among patients with conduct disorder. Adolescents with conduct disorder had an increased risk of developing any STI later in life compared with those without conduct disorder. Long-term use of SGAs was associated with a lower risk of subsequent STI.

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Funding

The study was sponsored by grants from the Ministry of Science and Technology, Taiwan (101-2314-B-010-060, 102-2314-B-010-060, 107-2314-B-075-063-MY3) and Taipei Veterans General Hospital (V106B-020, V107B-010, V107C-181). Funding source had no role in any process of study.

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Authors and Affiliations

  1. Department of Psychiatry, Taipei Veterans General Hospital, No. 201, Shih-Pai Road, Sec. 2, Taipei, 11217, Taiwan, ROC

    Yu-Tse Lin, Ju-Wei Hsu, Kai-Lin Huang, Shih-Jen Tsai, Tung-Ping Su, Cheng-Ta Li, Wei-Chen Lin, Ya-Mei Bai & Mu-Hong Chen

  2. Department of Psychiatry, College of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC

    Yu-Tse Lin, Ju-Wei Hsu, Kai-Lin Huang, Shih-Jen Tsai, Tung-Ping Su, Cheng-Ta Li, Wei-Chen Lin, Ya-Mei Bai & Mu-Hong Chen

  3. Department of Family Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC

    Tzeng-Ji Chen

  4. Institute of Hospital and Health Care Administration, National Yang-Ming University, Taipei, Taiwan, ROC

    Tzeng-Ji Chen

  5. Department of Psychiatry, Cheng Hsin General Hospital, Taipei, Taiwan, ROC

    Tung-Ping Su

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  1. Yu-Tse Lin
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  2. Ju-Wei Hsu
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  5. Tung-Ping Su
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  7. Wei-Chen Lin
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  8. Tzeng-Ji Chen
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  9. Ya-Mei Bai
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  10. Mu-Hong Chen
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Correspondence to Ya-Mei Bai or Mu-Hong Chen.

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Lin, YT., Hsu, JW., Huang, KL. et al. Sexually transmitted infections among adolescents with conduct disorder: a nationwide longitudinal study. Eur Child Adolesc Psychiatry 30, 1187–1193 (2021). https://doi.org/10.1007/s00787-020-01605-5

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  • DOI: https://doi.org/10.1007/s00787-020-01605-5

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