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Assessment of early discomfort and wound healing outcomes after periodontal surgery with and without enamel matrix derivative: an observational retrospective case-control study

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Abstract

Objective

The aim of this study was to evaluate and compare early postoperative discomfort and wound healing outcomes between patients who underwent periodontal surgery with and without enamel matrix derivative (EMD), using retrospective questionnaires and postoperative clinical examinations.

Materials and methods

All enrolled patients filled out the self-report questionnaire after suture removal. The severity and duration of subjective pain and swelling were evaluated using visual analog scale (VAS) scores and wound healing parameters (dehiscence/fenestration, spontaneous bleeding, persistent swelling, and ulceration). Chi-squared tests, two-tailed independent t tests, analysis of variance, and multiple logistic regression analysis were performed to identify significant differences between the two groups (surgery with EMD and surgery without EMD).

Results

The severity of pain and swelling did not differ between patients who underwent surgery with and without EMD, but the durations of pain (P < 0.001) and swelling (P = 0.019) were significantly lower in patients who underwent surgery with EMD. Multivariate analysis with adjustment for confounding variables showed that wound healing outcomes including dehiscence/fenestration, spontaneous bleeding, and ulceration did not differ significantly between the two groups, and only persistent swelling showed significant differences (odds ratio 4.03, 95% CI 1.17–13.78; P = 0.026).

Conclusions

No difference was observed in the severity of early postoperative discomfort and wound healing outcomes between patients who underwent surgery with and without EMD, but shorter durations of postoperative pain and swelling were evident in patients who underwent surgery with EMD.

Clinical relevance

Adjunctive EMD used in periodontal surgery has clinical advantages for reducing the durations of postoperative pain and swelling.

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Funding

This research was supported by Wonkwang University in 2019.

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Authors and Affiliations

  1. Department of Periodontology, Daejeon Dental Hospital, Institute of Wonkwang Dental Research, Wonkwang University College of Dentistry, 77 Dunsan-ro, Seo-gu, Daejeon, 35233, South Korea

    Jae-Hong Lee, Ye-Sol Park, Yeon-Tae Kim, Do-Hyung Kim & Seong-Nyum Jeong

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Correspondence to Jae-Hong Lee.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

The study was approved by the Institutional Review Board (IRB) of Daejeon Dental Hospital, Wonkwang University (approval no. W1807/001-001).

Informed consent

All enrolled patients provided written fully informed consent in accordance with the IRB guidelines, and the study was conducted in accordance with the Declaration of Helsinki and the Guidelines on Good Clinical Practice.

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Lee, JH., Park, YS., Kim, YT. et al. Assessment of early discomfort and wound healing outcomes after periodontal surgery with and without enamel matrix derivative: an observational retrospective case-control study. Clin Oral Invest 24, 229–237 (2020). https://doi.org/10.1007/s00784-019-02941-w

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  • DOI: https://doi.org/10.1007/s00784-019-02941-w

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