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Effects of probiotics in periodontal diseases: a systematic review

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Abstract

Objectives

This study was designed to determine the effects of probiotics in prevention and/or treatment of periodontal diseases.

Materials and methods

We performed broad searches in the MEDLINE, Embase, and Cochrane databases and selected articles that satisfied the description of randomized clinical trials comparing the administration of probiotics versus placebo or another intervention to prevent or treat periodontal diseases in adult patients.

Results

Four randomized clinical trials were analyzed in the final review process. For the primary outcome, probing pocket depth, there would be no clinical beneficial effect of probiotics. For secondary outcomes, probiotics have shown small benefits on plaque index and gingival inflammation.

Conclusions

Based on the results of this review, the effectiveness of probiotics on the prevention and treatment of periodontal diseases is questionable. There is currently insufficient evidence demonstrating the benefits of systematic preventative use of probiotics in patients with periodontal diseases.

Clinical relevance

The use of probiotics are described to prevent or treat periodontal diseases in some clinical trials; therefore, a systematic review of the evidence for the effect of periodontal diseases is needed.

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Conflicts of interest and source of funding statement

None of the authors of this review declares a conflict of interest or obtained any kind of financing or support from any company related to the production of probiotics. This investigation did not receive any private financial support.

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Authors and Affiliations

  1. Evidence Based Dentistry Unit, School of Dentistry, Universidad de Chile, Sergio Livingstone 943 Independencia, Santiago, Chile

    Nicolás Yanine, Ignacio Araya, Romina Brignardello-Petersen, Alonso Carrasco-Labra & Julio Villanueva

  2. Department of Maxillofacial Surgery, School of Dentistry, Universidad de Chile, Sergio Livingstone 943 Independencia, Santiago, Chile

    Nicolás Yanine, Ignacio Araya, Alonso Carrasco-Labra & Julio Villanueva

  3. Department of Pathology, School of Dentistry, Universidad de Chile, Sergio Livingstone 943 Independencia, Santiago, Chile

    Romina Brignardello-Petersen

  4. Faculty of Odontology–Oral Medicine, Universidad Complutense de Madrid, Madrid, Spain

    Almudena González

  5. Faculty of Odontology–Buccofacial Prostheses, Universidad Complutense de Madrid, Madrid, Spain

    Arelis Preciado

  6. Faculty of Odontology–Periodontology, Universidad Complutense de Madrid, Madrid, Spain

    Mariano Sanz

  7. Faculty of Odontology–Orthodontics, Universidad Complutense de Madrid, Madrid, Spain

    Conchita Martin

Authors
  1. Nicolás Yanine
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  2. Ignacio Araya
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  3. Romina Brignardello-Petersen
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  4. Alonso Carrasco-Labra
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  5. Almudena González
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  6. Arelis Preciado
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  7. Julio Villanueva
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  8. Mariano Sanz
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  9. Conchita Martin
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Corresponding author

Correspondence to Nicolás Yanine.

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Yanine, N., Araya, I., Brignardello-Petersen, R. et al. Effects of probiotics in periodontal diseases: a systematic review. Clin Oral Invest 17, 1627–1634 (2013). https://doi.org/10.1007/s00784-013-0990-7

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  • DOI: https://doi.org/10.1007/s00784-013-0990-7

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