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The evaluation of the effects of hyperbaric oxygen therapy on new bone formation obtained by distraction osteogenesis in terms of consolidation periods

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Abstract

Objective

The aim of this study was to evaluate the effect of hyperbaric oxygen therapy on new bone formation obtained by distraction osteogenesis in long- or short-term consolidation periods.

Materials and methods

Twenty-four rabbits were used. The animals were divided into two groups of 12 animals each, and vertical mandibular distraction osteogenesis was performed. Hyperbaric oxygen therapy was administered in the first group. Each group was subdivided into two subgroups according to the 30- and 60-day consolidation period. The acquired bone amounts were compared according to their radiographic density and histopathology.

Results

Histopathologically, in the experimental group, callus formation was increased and the new bone was more mineralized. According to the radiographic densitometry analyses, there were no statistically significant differences between the 30-day consolidated subgroups of the experimental group and the 60-day consolidated subgroup of the control group (p = 0.873).

Conclusion

Hyperbaric oxygen therapy can be used to increase the quality and the quantity of bone and to decrease the maturation time which may shorten the consolidation period of vertical distraction osteogenesis.

Clinical relevance

The effect of hyperbaric oxygen therapy on vertical distraction osteogenesis procedure according to consolidation periods has been determined. Hyperbaric oxygen therapy may increase the quality and the quantity of bone and shorten the consolidation period.

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Authors and Affiliations

  1. Ankara Mevki Military Hospital, Ankara, Turkey

    Ibrahim Mutlu

  2. Department of Oral and Maxillofacial Surgery, Gülhane Military Medical Academy (GMMA), Ankara, Turkey

    Yavuz Sinan Aydintug & Gurkan Rasit Bayar

  3. Department of Pathology, Gülhane Military Medical Academy (GMMA), Ankara, Turkey

    Ayper Kaya

  4. Department of Oral and Maxillofacial Surgery, Haydarpasa Training Hospital, Gülhane Military Medical Academy (GMMA), Ankara, Turkey

    Berkay Tolga Suer

  5. Commando Troop No: 5, Surgical Infirmary, 2nd Army Corps, 17760, Gokceada, Canakkale, Turkey

    Aydin Gulses

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  1. Ibrahim Mutlu
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  2. Yavuz Sinan Aydintug
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  3. Ayper Kaya
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Correspondence to Aydin Gulses.

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Mutlu, I., Aydintug, Y.S., Kaya, A. et al. The evaluation of the effects of hyperbaric oxygen therapy on new bone formation obtained by distraction osteogenesis in terms of consolidation periods. Clin Oral Invest 16, 1363–1370 (2012). https://doi.org/10.1007/s00784-011-0644-6

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  • DOI: https://doi.org/10.1007/s00784-011-0644-6

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