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Synthesis of 3,6-Disubstituted Tetrahydro-S-triazolo[3,4-b][1,3,5]thiadiazines

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Molecules

Abstract

Ten novel 3,6-disubstituted tetrahydro-S-triazolo[3,4-b][1,3,5]thiadiazines 2 have been synthesized by the double Mannich reaction of 3-aryl-5-mercapto-1,2,4-triazole with various aromatic amines and formaldehyde in the presence of ethanol-HCl solution. The structure of these compounds was determined by elemental analysis, IR, NMR and MS. Their antibacterial activities against E. coli, B. bob and S. aureus have been tested.

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Authors and Affiliations

  1. North Campus, University of Science and Technology of China, Room 210, Apartment #1, 230026, Hefei, P. R. China

    Zhongyi Wang

  2. Department of Chemical Physics, University of Science and Technology of China, 230026, Hefei, P. R. China

    Zhongyi Wang & Tianpa You

  3. Department of Chemistry, Anhui Normal University, 24100, Wuhu, P. R. China

    Haijian Shi & Haoxin Shi

Authors
  1. Zhongyi Wang
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  2. Tianpa You
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  3. Haijian Shi
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  4. Haoxin Shi
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Wang, Z., You, T., Shi, H. et al. Synthesis of 3,6-Disubstituted Tetrahydro-S-triazolo[3,4-b][1,3,5]thiadiazines. Molecules 1, 89–92 (1996). https://doi.org/10.1007/s007830050015

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  • DOI: https://doi.org/10.1007/s007830050015

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