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Critical discussion of the applications of metal complexes for 2-photon photodynamic therapy

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Abstract

Photodynamic therapy is a light-activated medical technique, which has received increasing attention within the last decade to treat various diseases including bacterial, viral or fungal infections as well as cancer. To overcome the limitations of the currently clinically applied photosensitizers based on a tetrapyrrolic scaffold, metal complexes are sought to be an interesting alternative. While these complexes show attractive photophysical and biological properties, the majority of these compounds are excited using visible light, which is associated with a poor tissue penetration. To circumvent this drawback, increasing attention has been devoted towards the use of 2-Photon instead of 1-Photon irradiation. In this mini-review, the metal complexes prepared in view of 2P-PDT are reviewed and the requirements these compounds need to fulfil to be of interest are critically discussed.

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Acknowledgments

This work was financially supported by an ERC Consolidator Grant PhotoMedMet to G. G. (GA 681679) and has received support under the program “Investissements d’Avenir” launched by the French Government and implemented by the ANR with the reference ANR-10-IDEX-0001-02 PSL (G. G.), the National Science Foundation of China (Nos. 21525105 and 21778079 for H. C.) and the 973 Program (No. 2015CB856301 for H. C.).

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  1. Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA

    Johannes Karges

  2. MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, People’s Republic of China

    Hui Chao

  3. Laboratory for Inorganic Chemical Biology, Institute of Chemistry for Life and Health Sciences, Chimie ParisTech, PSL University, CNRS, 75005, Paris, France

    Gilles Gasser

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Karges, J., Chao, H. & Gasser, G. Critical discussion of the applications of metal complexes for 2-photon photodynamic therapy. J Biol Inorg Chem 25, 1035–1050 (2020). https://doi.org/10.1007/s00775-020-01829-5

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