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EPR interpretation, magnetism and biological study of a Cu(II) dinuclear complex assisted by a schiff base precursor

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Abstract

A new Cu(II) dinuclear complex, Cu2L2 (1) was afforded employing the potentially pentatentate Schiff base precursor H2L, a refluxed product of o-vanillin and diethylenetriamine in methanol. Complex 1 was systematically characterized by FTIR, UV–Vis, emission and EPR spectrometry. The single crystal X-ray diffraction analysis of 1 reveals that the copper atom exhibits a distorted square planar geometry, comprising two pairs of phenolato-O and imine-N donors from two different H2L ligands. The temperature dependent magnetic interpretation agrees with the existence of weak antiferromagnetic interactions between the bridging dinuclear Cu(II) ions. A considerable body of experimental evidence has been accumulated to elucidate the magneto-structural relationship in this dinuclear Cu(II) complex by DFT computation. Both the ligand and complex 1 exhibit anti-mycobacterial activity and considerable efficacy on M. tuberculosis H37Ra (ATCC 25177) and M. tuberculosis H37Rv (ATCC 25618) strains. The practical applicability of the ligand and complex 1 has been examined in living cells (African Monkey Vero Cells). The MTT assay proves the non-toxicity of the probe up to 100 mg mL−1.

Graphical abstract

A new homometallic dinuclear Cu(II) complex is afforded with a tetradentate Schiff base precursor. EPR interpretation and temperature dependent magnetic studies show that complex 1 has weak antiferromagnetic coupling and DFT computation is governed to explain the magneto-structural correlation.

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Acknowledgements

KD and CS would like to thank the Council of Scientific and Industrial Research (CSIR, Sanction No. 01(2731)/13/EMR-II,) New Delhi, India to carry out the present study. A.F. thanks the DGICYT of Spain (projects CTQ2014-57393-C2-1-P and CONSOLIDER INGENIO 2010 CSD2010-00065, FEDER funds) for financial support. We thank the CTI (UIB) for computational facilities.

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Authors and Affiliations

  1. Department of Chemistry, Jadavpur University, Kolkata, 700032, India

    Kuheli Das, Chiranjit Patra, Chandana Sen & Chittaranjan Sinha

  2. Institute of Chemistry, Academia Sinica, Nankang, Taipei, 115, Taiwan

    Kuheli Das, Amitabha Datta, Belete B. Beyene & Chen-Hsiung Hung

  3. Dipartimento di Chimica, Universita degli Studi di Parma, Viale delle Scienze, 17/A, 43124, Parma, Italy

    Chiara Massera

  4. Dipartimento di Chimica e Farmacia, Università di Sassari, Via Vienna 2, 07100, Sassari, Italy

    Eugenio Garribba

  5. Departament de Química Inorgànica, Facultat de Química, Universitat de Barcelona, Martíi Franquès, 1-11, 08028, Barcelona, Catalunya, Spain

    Mohamed Salah El Fallah

  6. Department of Biology, Faculty of Sciences and Arts, University of Balikesir, Cagis Campus, 10145, Balıkesir, Turkey

    Tulin Askun & Pinar Celikboyun

  7. CEISAM UMR CNRS 6230, Université de Nantes, 2 rue de la Houssinière, BP 92208, 44322, Nantes Cedex 3, France

    Daniel Escudero

  8. Departament de Quimica, Universitat de les Illes Balears, Crta. de Valldemossa km 7.5, 07122, Palma de Mallorca (Baleares), Spain

    Antonio Frontera

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Das, K., Patra, C., Sen, C. et al. EPR interpretation, magnetism and biological study of a Cu(II) dinuclear complex assisted by a schiff base precursor. J Biol Inorg Chem 22, 481–495 (2017). https://doi.org/10.1007/s00775-016-1428-x

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