Skip to main content
SpringerLink
Log in

Disability for daily living is a predictor for joint replacement in patients with end-stage knee osteoarthritis

  • Original Article
  • Published:
Journal of Bone and Mineral Metabolism Aims and scope Submit manuscript

Abstract

The objective indicators which reflect the past results of end-stage knee osteoarthritis (OA) patients who have already received total knee arthroplasty (TKA) could be helpful for physicians to discuss with patients who are considering TKA. The aim of this prospective cohort study was to examine whether we could predict the knee OA patients who would receive TKA in advance based on baseline data, and to set cut-off points for receiving TKA. The two-hundred and forty end-stage medial-type knee OA patients were enrolled and followed up for 6 months while performing therapeutic exercises. Radiographic findings, visual analog scale for pain and a patient-oriented outcome measure, the Japanese Knee Osteoarthritis Measure (JKOM), were recorded at baseline. Relative risks (RRs) using the area under the curve (AUC) for a receiver operating characteristic (ROC) curve were calculated to evaluate several scores for receiving TKA. While 119 patients (55.3 %) did not undergo TKA, the remaining 96 patients (44.7 %) underwent TKA during this period. The AUCs of the ROC curve for the JKOM total score [0.71 (95 % CI 0.64–0.79)] were higher than those for radiographic parameters. Among the JKOM subcategories, JKOM category III, which indicates the condition in daily life, showed the highest AUC of 0.72 (0.65–0.80). The JKOM total score (65/100) and JKOM category III score (17/40) showed RRs of 2.20 (1.33–3.63) and 1.95 (1.18–3.22) for receiving TKA, respectively. The presence of disability in daily living was found to be an important factor determining whether the patient should undergo TKA.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Carr AJ, Robertsson O, Graves S, Price AJ, Arden NK, Judge A, Beard DJ (2012) Knee replacement. Lancet 379:1331–1340

    Article  PubMed  Google Scholar 

  2. Dieppe P, Basler HD, Chard J, Croft P, Dixon J, Hurley M, Lohmander S, Raspe H (1999) Knee replacement surgery for osteoarthritis: effectiveness, practice variations, indications and possible determinants of utilization. Rheumatology 38:73–83

    Article  CAS  PubMed  Google Scholar 

  3. Wise BL, Felson DT, Clancy M, Niu J, Neogi T, Lane NE, Hietpas J, Curtis JR, Bradley LA, Torner JC, Zhang Y (2011) Consistency of knee pain and risk of knee replacement: the multicenter osteoarthritis study. J Rheumatol 38:1390–1395

    Article  PubMed Central  PubMed  Google Scholar 

  4. Dieppe P (2011) Who should have a joint replacement? A plea for more ‘phronesis’. Osteoarthritis Cartilage 19:145–146

    Article  CAS  PubMed  Google Scholar 

  5. Dieppe P, Lim K, Lohmander S (2011) Who should have knee joint replacement surgery for osteoarthritis? Int J Rheum Dis 14:175–180

    Article  PubMed  Google Scholar 

  6. Naylor CD, Williams JI (1996) Primary hip and knee replacement surgery: Ontario criteria for case selection and surgical priority. Qual Health Care 5:20–30

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  7. Maillefert JF, Hawker GA, Gossec L, Mahomed NN, Lohmander S, Dieppe PA, Zanoli G, Hochberg MC, Dougados M (2005) Concomitant therapy: an outcome variable for musculoskeletal disorders? Part 2: total joint replacement in osteoarthritis trials. J Rheumatol 32:2449–2451

    PubMed  Google Scholar 

  8. Gossec L, Tubach F, Baron G, Ravaud P, Logeart I, Dougados M (2005) Predictive factors of total hip replacement due to primary osteoarthritis: a prospective 2 year study of 505 patients. Ann Rheum Dis 64:1028–1032

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  9. Hawker GA, Guan J, Croxford R, Coyte PC, Glazier RH, Harvey BJ, Wright JG, Williams JI, Badley EM (2006) A prospective population-based study of the predictors of undergoing total joint arthroplasty. Arthritis Rheum 54:3212–3220

    Article  PubMed  Google Scholar 

  10. Gossec L, Hawker G, Davis AM, Maillefert JF, Lohmander LS, Altman R, Cibere J, Conaghan PG, Hochberg MC, Jordan JM, Katz JN, March L, Mahomed N, Pavelka K, Roos EM, Suarez-Almazor ME, Zanoli G, Dougados M (2007) OMERACT/OARSI initiative to define states of severity and indication for joint replacement in hip and knee osteoarthritis. J Rheumatol 34:1432–1435

    PubMed  Google Scholar 

  11. Gossec L, Paternotte S, Bingham CO 3rd, Clegg DO, Coste P et al (2011) OARSI/OMERACT initiative to define states of severity and indication for joint replacement in hip and knee osteoarthritis. An omeract 10 special interest group. J Rheumatol 38:1765–1769

    Article  PubMed Central  PubMed  Google Scholar 

  12. Gossec L, Paternotte S, Maillefert JF, Combescure C, Conaghan PG et al (2011) The role of pain and functional impairment in the decision to recommend total joint replacement in hip and knee osteoarthritis: an international cross-sectional study of 1909 patients. Report of the OARSI-OMERACT task force on total joint replacement. Osteoarthritis Cartilage 19:147–154

    Article  CAS  PubMed  Google Scholar 

  13. Hawker GA, Wright JG, Coyte PC, Williams JI, Harvey B, Glazier R, Wilkins A, Badley EM (2001) Determining the need for hip and knee arthroplasty: the role of clinical severity and patients’ preferences. Med Care 39:206–216

    Article  CAS  PubMed  Google Scholar 

  14. Woolhead GM, Donovan JL, Chard JA, Dieppe PA (2002) Who should have priority for a knee joint replacement? Rheumatology 41:390–394

    Article  CAS  PubMed  Google Scholar 

  15. Yong PF, Milner PC, Payne JN, Lewis PA, Jennison C (2004) Inequalities in access to knee joint replacements for people in need. Ann Rheum Dis 63:1483–1489

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  16. Ackerman IN, Dieppe PA, March LM, Roos EM, Nilsdotter AK, Brown GC, Sloan KE, Osborne RH (2009) Variation in age and physical status prior to total knee and hip replacement surgery: a comparison of centers in Australia and Europe. Arthritis Rheum 61:166–173

    Article  PubMed  Google Scholar 

  17. Dieppe P, Judge A, Williams S, Ikwueke I, Guenther KP, Floeren M, Huber J, Ingvarsson T, Learmonth I, Lohmander LS, Nilsdotter A, Puhl W, Rowley D, Thieler R, Dreinhoefer K (2009) Variations in the pre-operative status of patients coming to primary hip replacement for osteoarthritis in European orthopaedic centres. BMC Musculoskelet Disord 10:19

    Article  PubMed Central  PubMed  Google Scholar 

  18. Judge A, Welton NJ, Sandhu J, Ben-Shlomo Y (2009) Geographical variation in the provision of elective primary hip and knee replacement: the role of socio-demographic, hospital and distance variables. J Public Health (Oxf) 31:413–422

    Article  Google Scholar 

  19. Judge A, Welton NJ, Sandhu J, Ben-Shlomo Y (2010) Equity in access to total joint replacement of the hip and knee in England: cross sectional study. BMJ 341:c4092

    Article  PubMed Central  PubMed  Google Scholar 

  20. Cobos R, Latorre A, Aizpuru F, Guenaga JI, Sarasqueta C, Escobar A, Garcia L, Herrera-Espineira C (2010) Variability of indication criteria in knee and hip replacement: an observational study. BMC Musculoskelet Disord 11:249

    Article  PubMed Central  PubMed  Google Scholar 

  21. Kawasaki T, Kurosawa H, Ikeda H, Kim SG, Osawa A, Takazawa Y, Kubota M, Ishijima M (2008) Additive effects of glucosamine or risedronate for the treatment of osteoarthritis of the knee combined with home exercise: a prospective randomized 18-month trial. J Bone Miner Metab 26:279–287

    Article  CAS  PubMed  Google Scholar 

  22. Kawasaki T, Kurosawa H, Ikeda H, Takazawa Y, Ishijima M, Kubota M, Kajihara H, Maruyama Y, Kim SG, Kanazawa H, Doi T (2009) Therapeutic home exercise versus intraarticular hyaluronate injection for osteoarthritis of the knee: 6-month prospective randomized open-labeled trial. J Orthop Sci 14:182–191

    Article  PubMed  Google Scholar 

  23. Altman R, Asch E, Bloch D, Bole G, Borenstein D et al (1986) Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and therapeutic criteria Committee of the American Rheumatism Association. Arthritis Rheum 29:1039–1049

    Article  CAS  PubMed  Google Scholar 

  24. Kellgren JH, Lawrence JS (1957) Radiological assessment of osteo-arthrosis. Ann Rheum Dis 16:494–502

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  25. Buckland-Wright JC, Macfarlane DG, Williams SA, Ward RJ (1995) Accuracy and precision of joint space width measurements in standard and macroradiographs of osteoarthritic knees. Ann Rheum Dis 54:872–880

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  26. Ravaud P, Auleley GR, Chastang C, Rousselin B, Paolozzi L, Amor B, Dougados M (1996) Knee joint space width measurement: an experimental study of the influence of radiographic procedure and joint positioning. Br J Rheumatol 35:761–766

    Article  CAS  PubMed  Google Scholar 

  27. Altman RD, Gold GE (2007) Atlas of individual radiographic features in osteoarthritis, revised. Osteoarthritis Cartilage 15 Suppl A:A1–A56

    Article  CAS  PubMed  Google Scholar 

  28. Akai M, Doi T, Fujino K, Iwaya T, Kurosawa H, Nasu T (2005) An outcome measure for Japanese people with knee osteoarthritis. J Rheumatol 32:1524–1532

    PubMed  Google Scholar 

  29. Liu L, Ishijima M, Futami I, Kaneko H, Kubota M, Kawasaki T, Matsumoto T, Kurihara H, Ning L, Xu Z, Ikeda H, Takazawa Y, Saita Y, Kimura Y, Xu S, Kaneko K, Kurosawa H (2010) Correlation between synovitis detected on enhanced-magnetic resonance imaging and a histological analysis with a patient-oriented outcome measure for japanese patients with end-stage knee osteoarthritis receiving joint replacement surgery. Clin Rheumatol 29:1185–1190

    Article  PubMed  Google Scholar 

  30. Ishijima M, Watari T, Naito K, Kaneko H, Futami I, Yoshimura-Ishida K, Tomonaga A, Yamaguchi H, Yamamoto T, Nagaoka I, Kurosawa H, Poole RA, Kaneko K (2011) Relationships between biomarkers of cartilage, bone, synovial metabolism and knee pain provide insights into the origins of pain in early knee osteoarthritis. Arthritis Res Ther 13:R22

    Article  PubMed Central  PubMed  Google Scholar 

  31. Pham T, Van Der Heijde D, Altman RD, Anderson JJ, Bellamy N, Hochberg M, Simon L, Strand V, Woodworth T, Dougados M (2004) OMERACT-OARSI initiative: Osteoarthritis Research Society International set of responder criteria for osteoarthritis clinical trials revisited. Osteoarthritis Cartilage 12:389–399

    Article  CAS  PubMed  Google Scholar 

  32. Kubota M, Ishijima M, Kurosawa H, Liu L, Ikeda H, Osawa A, Takazawa Y, Kawasaki T, Saita Y, Kimura Y, Kaneko K (2010) A longitudinal study of the relationship between the status of bone marrow abnormalities and progression of knee osteoarthritis. J Orthop Sci 15:641–646

    Article  PubMed  Google Scholar 

  33. Ishijima M, Sakamoto Y, Yamanaka M, Tokita A, Kitahara K, Kaneko H, Kurosawa H (2009) Minimum required vitamin D level for optimal increase in bone mineral density with alendronate treatment in osteoporotic women. Calcif Tissue Int 85:398–404

    Article  CAS  PubMed  Google Scholar 

  34. Hawker GA, Wright JG, Coyte PC, Williams JI, Harvey B, Glazier R, Badley EM (2000) Differences between men and women in the rate of use of hip and knee arthroplasty. N Engl J Med 342:1016–1022

    Article  CAS  PubMed  Google Scholar 

  35. Laslett Ll, Kingsbury Sr, Hensor Em, Bowes Ma, Conaghan Pg (2013) Effect of bisphosphonate use in patients with symptomatic and radiographic knee osteoarthritis: data from the osteoarthritis initiative. Ann Rheum Dis (Epub ahead of print)

Download references

Acknowledgments

We wish to thank for Dr. Takayuki Kawasaki for his valuable help in data collection. This study was funded in part by a High Technology Research Center Grant from the Ministry of Education, Culture, Sports, Science and Technology, Japan (to MI and KK).

Conflict of interest

All authors have no conflicts of interest.

Author information

Authors and Affiliations

  1. Department of Medicine for Orthopaedics and Motor Organ, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan

    Lizu Liu, Muneaki Ishijima, Haruka Kaneko, Ippei Futami, Ryo Sadatsuki, Shinnosuke Hada, Anwarjan Yusup, Mitsuaki Kubota, Yoshitomo Saita, Yuji Takazawa, Hiroshi Ikeda & Kazuo Kaneko

  2. Sportology Center, Juntendo University Graduate School of Medicine, Tokyo, Japan

    Lizu Liu, Muneaki Ishijima & Kazuo Kaneko

  3. Department of Orthopaedics, Juntendo Tokyo Metropolitan Koto Geriatric Medical Center, Tokyo, Japan

    Yukio Shimura & Hisashi Kurosawa

Authors
  1. Lizu Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Muneaki Ishijima
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Haruka Kaneko
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ippei Futami
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ryo Sadatsuki
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Shinnosuke Hada
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Anwarjan Yusup
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Yukio Shimura
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Mitsuaki Kubota
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Yoshitomo Saita
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Yuji Takazawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Hiroshi Ikeda
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Hisashi Kurosawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. Kazuo Kaneko
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Muneaki Ishijima.

Electronic supplementary material

About this article

Cite this article

Liu, L., Ishijima, M., Kaneko, H. et al. Disability for daily living is a predictor for joint replacement in patients with end-stage knee osteoarthritis. J Bone Miner Metab 32, 192–199 (2014). https://doi.org/10.1007/s00774-013-0487-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00774-013-0487-0

Keywords

Search

Navigation