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Dissimilarity of femur aging in men and women from a Nationwide Survey in Korea (KNHANES IV)

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Abstract

In light of the differences in hip fracture rates between men and women of different ages, age-related changes in bone structure that lead to bone fragility might differ depending on both age and gender. To investigate age-related bone loss and geometric deterioration of the femur, hip scans of 1,504 men and 2,076 women aged 19–92 years acquired during the Fourth Korean National Health and Nutrition Examination Survey (KNHANES IV) using dual-energy X-ray absorptiometry (DXA) were analyzed with a structural analysis program. Cross-sectional area and cortical thickness with bone mineral density in men started to decline from the third decade and continued to decline at a constant rate. However, in women, these parameters remained nearly constant until the fifth decade and then declined at a more rapid rate than that seen in men. Consequently, changes in the buckling ratio, earlier onset, and continuation of increase over the lifetime were observed in men. A relatively later onset with a greater acceleration with aging was observed in women. Taken together, there were obvious gender and age differences in structural trends with age. Bone aging, i.e., bone loss and geometric deterioration, actually begins at a young age, especially in men, and osteoporosis prevention strategies should target not only the elderly but also younger individuals.

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Acknowledgments

This work was supported by the National Research Foundation of Korea (NRF) Grant funded by the Korea government (MEST) (No. 20110001024). We also express our heartfelt thanks to the Korean Osteoporosis Society.

Conflict of interest

The authors disclose that they have no conflicting interests in this work.

Author information

Authors and Affiliations

  1. Division of Endocrinology, Department of Internal Medicine, Institute of Endocrine Research, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120−752, Korea

    Kyoung Min Kim, Jung Soo Lim, Kwang Joon Kim, Yumie Rhee & Sung-Kil Lim

  2. Division of Endocrinology and Metabolism, Department of Internal Medicine, Dongguk University Ilsan Hospital, Goyang, Gyeonggi-do, Korea

    Han Seok Choi

  3. Department of Family Medicine, College of Medicine, Kwandong University, Gangneung, Gangwon-do, Korea

    Han Jin Oh

  4. Department of Obstetrics and Gynecology, College of Medicine, Inje University Sanggye Paik Hospital, Seoul, Korea

    Hoon Choi

  5. Division of Endocrinology and Metabolism, Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea

    Woong Hwan Choi

  6. Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, Korea

    Jung Gu Kim

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  1. Kyoung Min Kim
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  2. Jung Soo Lim
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  9. Jung Gu Kim
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  10. Sung-Kil Lim
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Correspondence to Sung-Kil Lim.

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Kim, K.M., Lim, J.S., Kim, K.J. et al. Dissimilarity of femur aging in men and women from a Nationwide Survey in Korea (KNHANES IV). J Bone Miner Metab 31, 144–152 (2013). https://doi.org/10.1007/s00774-012-0386-9

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  • DOI: https://doi.org/10.1007/s00774-012-0386-9

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