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Ser/Thr kinases and polyamines in the regulation of non-canonical functions of elongation factor 1A

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Abstract

The link between eukaryotic translation elongation factor 1A (eEF1A) and signal transduction pathways through the regulatory mechanism of phosphorylation has never been considered. In this review, we focus on the different kinases that recognize the Ser and Thr residues of the eEF1A1 and eEF1A2 isoforms and regulate their involvement in different cellular processes like cell survival and apoptosis. In this context, polyamines seem to play a role in the regulation of the translation elongation process by modulating the Ser/Thr kinases involved in the phosphorylation of translation elongation factors.

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Abbreviations

CDK:

Cyclin-dependent kinase

DAG:

Diacylglycerol

GEF:

Guanine-nucleotide exchange factor

eEF1A:

Eukaryotic elongation factor 1A

eEF1B:

Eukaryotic guanine-nucleotide exchange factor

ERK:

Extracellular signal-regulated kinase

ERM:

Ezrin, radixin, moesin proteins

GEF:

Guanine-nucleotide exchange factor

HCC:

Human hepatocellular carcinoma

HSV:

Herpes simplex virus

MAPK:

Mitogen-activated protein kinase

mTOR:

Mammalian target of rapamycin

BDNF:

Brain-derived neurotrophic factor

INFα:

Interferon α

JNK-1:

c-Jun N-terminal kinase

PMA:

Phorbol 12-myristate 13-acetate

PKC:

Protein kinase C

TGF-β:

Transforming growth factor β

MAPK:

Mitogen-activated protein kinase

MDM4:

Murine double minute 4

MBS:

Myosin-binding subunit

MEK:

MAPK/ERK kinase

MLC:

Myosin light chain

MDM4:

Mouse double minute homolog 4

MS:

Mass spectrometry

mTOR:

Mammalian target of rapamycin

Myc:

Myelocytomatosis oncogene cellular homologe

IF5A:

Eukaryotic initiation factor 5A

EGFR:

Epidermal growth factor receptor

APAO:

Acetyl polyamine oxidase

PASKIN:

PAS Kinase

PI3K/AKT:

Phosphoinositide-3-kinase and protein kinase B

PtdIns:

Phosphatidylinositol 4,5-Bisphosphate

PtdSer:

Phosphatidylserine

RAS:

Reticular-activating system

SMO:

Spermine oxidase

SSAT:

Spermidine/spermine N1-acetyltransferase

TbR-I:

TGF-β receptor

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Acknowledgments

This work was supported by funds from Programmi di Ricerca Scientifica di Rilevante Interesse Nazionale (2012CK5RPF_004), PON Ricerca e Competitività 2007–2013 (PON01_02782) to PA, and University of Rome Sapienza, MIUR (Ministero dell’Istruzione, dell’Università e della Ricerca) and Regione Lazio (Prot. FILAS-RU-2014-1020) to EA. We also acknowledge the support of POR Campania FSE 2007–2013, Project CRÈME.

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Authors and Affiliations

  1. Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Via S. Pansini 5, 8031, Naples, Italy

    Nunzia Migliaccio, Nicola M. Martucci, Immacolata Ruggiero, Annalisa Lamberti & Paolo Arcari

  2. ERT, Research Technology GmbH, Sieboldstrasse 3, 97230, Estenfeld, Germany

    Carmen Sanges

  3. Department of Biochemical Sciences “A. Rossi Fanelli”, “SAPIENZA” University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy

    Shinji Ohkubo & Enzo Agostinelli

  4. CEINGE, Advanced Biotechnology Scarl, Via Gaetano Salvatore 486, 80145, Naples, Italy

    Paolo Arcari

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  1. Nunzia Migliaccio
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  2. Nicola M. Martucci
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  3. Immacolata Ruggiero
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Correspondence to Enzo Agostinelli or Paolo Arcari.

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Migliaccio, N., Martucci, N.M., Ruggiero, I. et al. Ser/Thr kinases and polyamines in the regulation of non-canonical functions of elongation factor 1A. Amino Acids 48, 2339–2352 (2016). https://doi.org/10.1007/s00726-016-2311-3

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  • DOI: https://doi.org/10.1007/s00726-016-2311-3

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