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Novel interactions of TG2 with heparan sulfate proteoglycans: reflection on physiological implications

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Abstract

This mini-review brings together information from publications and recent conference proceedings that have shed light on the biological interaction between transglutaminase-2 and heparan sulphate proteoglycans. We subsequently draw hypotheses of possible implications in the wound healing process. There is a substantial overlap in the action of transglutaminase-2 and the heparan sulphate proteoglycan syndecan-4 in normal and abnormal wound repair. Our latest findings have identified syndecan-4 as a possible binding and signalling partner of fibronectin-bound TG2 and support the idea that transglutaminase-2 and syndecan-4 act in synergy.

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Acknowledgments

We wish to thank Dr. H. Lortat-Jacob and Dr. C. Laguri (Institut de Biologie Structurale CNRS-CEA, Grenoble) for useful comments on the TG2 structure and potential heparin binding sites. We are grateful to Prof. M. Griffin (Aston University, Birmingham) for generous sharing of cell lines.

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Authors and Affiliations

  1. School of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham, UK

    E. A. M. Verderio & A. Scarpellini

  2. Academic Nephrology Unit (Sheffield Kidney Institute), The Medical School, The University of Sheffield, Beech Hill Road, Sheffield, UK

    T. S. Johnson

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  1. E. A. M. Verderio
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  2. A. Scarpellini
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  3. T. S. Johnson
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Correspondence to E. A. M. Verderio.

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Verderio, E.A.M., Scarpellini, A. & Johnson, T.S. Novel interactions of TG2 with heparan sulfate proteoglycans: reflection on physiological implications. Amino Acids 36, 671–677 (2009). https://doi.org/10.1007/s00726-008-0134-6

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  • DOI: https://doi.org/10.1007/s00726-008-0134-6

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