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Effect of hyperprolinemia on acetylcholinesterase and butyrylcholinesterase activities in rat

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Summary.

We observed here that acute proline (Pro) administration provoked a decrease (32%) of acetylcholinesterase (AChE) activity in cerebral cortex and an increase (22%) of butyrylcholinesterase (BuChE) activity in the serum of 29-day-old rats. In contrast, chronic administration of Pro did not alter AChE or BuChE activities. Furthermore, pretreatment of rats with vitamins E and C combined or alone, Nϖ-nitro-L-arginine methyl ester or melatonin prevented the reduction of AChE activity caused by acute Pro administration, suggesting the participation of oxidative stress in such effects.

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Authors and Affiliations

  1. Departamento de Bioquímica, ICBS, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil

    D. Delwing, F. Chiarani, C. M. D. Wannmacher, M. Wajner & A. T. S. Wyse

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  1. D. Delwing
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  2. F. Chiarani
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  3. C. M. D. Wannmacher
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  4. M. Wajner
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  5. A. T. S. Wyse
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Delwing, D., Chiarani, F., Wannmacher, C. et al. Effect of hyperprolinemia on acetylcholinesterase and butyrylcholinesterase activities in rat. Amino Acids 28, 305–308 (2005). https://doi.org/10.1007/s00726-005-0186-9

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  • DOI: https://doi.org/10.1007/s00726-005-0186-9

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