Summary.
The LIM domain is an evolutionary conserved double-zinc finger motif found in a variety of proteins exhibiting diverse biological roles. LIM domains have been observed to act as modular protein-binding interfaces mediating protein-protein interactions in the cytoplasm and the nucleus. Interaction of LIM domains with specific protein partners is now known to influence its subcellular localization and activity; however, no single binding motif has been identified as a common target for LIM domains. Several LIM domain-containing proteins associated with the actin cytoskeleton have been identified, playing a role in signal transduction and organization of the actin filaments during various cellular processes.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Received April 9, 2001¶Accepted October 7, 2001
Rights and permissions
About this article
Cite this article
Khurana, T., Khurana, B. & Noegel, A. LIM proteins: association with the actin cytoskeleton. Protoplasma 219, 1–12 (2002). https://doi.org/10.1007/s007090200000
Issue Date:
DOI: https://doi.org/10.1007/s007090200000