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Electrochemical fabrication of poly(l-alanine)-gold nanoparticle nanocomposite-modified electrode: application for determination and mechanism of antipsychotic drug olanzapine

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Abstract

This work presents a new electrochemical sensor based on poly(l-alanine) (l-Ala) (as a conducting polymer), and gold nanoparticles (AuNPs) coated with a pre-anodized pencil graphite electrode (pre-PGE). Electrosynthesis, preparation, and sensor characterization were studied by cyclic voltammetry, electrochemical impedance spectroscopy, and energy dispersive X-ray spectroscopy. Electrocatalytic activities of the sensor (AuNPs/poly(l-Ala)/pre-PGE) were compared with pre-PGE, poly(l-Ala)/pre-PGE. This polymer–nanoparticles-modified electrode was evaluated to determine olanzapine (OLA) by differential pulse voltammetry in Britton–Robinson buffer solution. The effect of each nanomaterial and pH was tested to investigate sensor performance. OLA's oxidation peak (0.850 V) was found linearly in the range of 0.271–1000.0 µM with a detection limit of 0.081 μM. The analytical applicability of the sensor was successfully carried out in pharmaceutical dosage forms, human urine, and human serum. Moreover, the electrochemical oxidation mechanism of the antipsychotic drug OLA was studied using cyclic voltammetry to understand its action mechanism and side effect.

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Data availability statement

The samples used were taken from the authors of this work in our laboratory conditions.

References

  1. Callaghan JT, Bergstrom RF, Ptak LR, Beasley CM (1999) Clin Pharmacokinet 37:177

    Article  CAS  Google Scholar 

  2. Townsend LK, Peppler WT, Bush ND, Wright DC (2018) Psychoneuroendocrinology 88:121

    Article  CAS  Google Scholar 

  3. Ikeda K, Ikawa K, Kozumi T, Yokoshige S, Horikawa S, Morikawa N (2012) Anal Bioanal Chem 403:1823

    Article  CAS  Google Scholar 

  4. Aman T, Firdous S, Nisa AU (2011) J Chem Soc Pak 27:163

    Google Scholar 

  5. Arvand M, Orangpour S, Ghodsi N (2015) RSC Adv 5:46095

    Article  CAS  Google Scholar 

  6. Shahrokhian S, Azimzadeh M, Hosseini P (2014) RSC Adv 4:40553

    Article  CAS  Google Scholar 

  7. Pisoschi AM, Cimpeanu C, Predoi G (2015). Open Chem. https://doi.org/10.1515/chem-2015-0099

    Article  Google Scholar 

  8. Rana A, Baig N, Saleh TA (2019) J Electroanal Chem 833:313

    Article  CAS  Google Scholar 

  9. Yılmaz B, Albayrak M, Kadıoğlu Y (2017) Celal Bayar Univ J Sci 13:216–226

    Google Scholar 

  10. Rao JP, Geckeler KE (2011) Prog Polym Sci 36:887

    Article  CAS  Google Scholar 

  11. Urçuk A, Yıldız C, Bayraktepe DE, Yazan Z (2022) Microchem J 181:107695

    Article  Google Scholar 

  12. Hu G, Ma Y, Guo Y, Shao S (2008) Electrochim Acta 53:6610

    Article  CAS  Google Scholar 

  13. Chandra P, Noh HB, Won MS, Shim YB (2011) Biosens Bioelectron 26:4442

    Article  CAS  Google Scholar 

  14. Li J, Zhou L, Han X, Liu H (2008) Sens Actuators B Chem 135:322

    Article  CAS  Google Scholar 

  15. Phongphut A, Chayasombat B, Cass AE, Sirisuk A, Phisalaphong M, Prichanont S, Thanachayanont C (2020) Appl Clay Sci 194:105704

    Article  CAS  Google Scholar 

  16. Bayraktepe DE, İnal EK, Yazan Z (2021) Microchem J 171:106812

    Article  Google Scholar 

  17. Heineman WR, Kissinger PT (1980) Anal Chem 52:138

    Article  Google Scholar 

  18. Compton RG, Banks CE (2018) Understanding voltammetry. World Scientific

    Book  Google Scholar 

  19. Baselt RC (2008) Disposition of toxic drugs and chemicals in man. Biomedical Publications, Foster City, California

    Google Scholar 

  20. Bacil RP, Garcia PH, de Araujo WR, Serrano SHP (2021) Electrochim Acta 368:137683

    Article  CAS  Google Scholar 

  21. Streeter I, Jenkinson SF, Fleet GW, Compton RG (2007) J Electroanal Chem 600:285

    Article  CAS  Google Scholar 

  22. Gosser DK (1993) Cyclic voltammetry: simulation and analysis of reaction mechanisms, vol 43. Wiley VCH, New York

    Google Scholar 

  23. Raggi MA, Casamenti G, Mandrioli R, Izzo G, Kenndler E (2000) J Pharm Biomed Anal 23:973

    Article  CAS  Google Scholar 

  24. Bıryol İ, Erk N (2003) Anal Lett 36:2497

    Article  Google Scholar 

  25. El-Shal MA (2013) Adv Pharm Bull 3:339

    Google Scholar 

  26. Yağmur S (2020) J Adv Res Nat Appl Sci 6:342

    Google Scholar 

  27. Ahmed HM, Mohamed MA, Salem WM (2015) Anal Methods 7:581

    Article  CAS  Google Scholar 

  28. Mohammadi-Behzad L, Gholivand MB, Shamsipur M, Gholivand K, Barati A, Gholami A (2016) Mater Sci Eng C 60:67

    Article  CAS  Google Scholar 

  29. Arvand M, Pourhabib A (2019) J Anal Chem 74:1096

    Article  Google Scholar 

  30. Arvand M, Palizkar B (2013) Mater Sci Eng C 33:4876

    Article  CAS  Google Scholar 

  31. Merli D, Dondi D, Pesavento M, Profumo A (2012) J Electroanal Chem 683:103

    Article  CAS  Google Scholar 

  32. Mashhadizadeh MH, Afshar E (2012) Electroanalysis 24:2193

    Article  CAS  Google Scholar 

  33. Shukla RP, Belmaker RH, Bersudsky Y, Ben-Yoav H (2020) J Neural Transm 127:291

    Article  CAS  Google Scholar 

  34. Muthusankar G, Sangili A, Chen SM, Karkuzhali R, Sethupathi M, Gopu G, Karthick S, Devi RK, Sengottuvelan N (2018) J Mol Liq 268:471

    Article  CAS  Google Scholar 

  35. Harisha KV, Swamy BK, Ganesh PS, Jayadevappa H (2019) J Electroanal Chem 832:486

    Article  CAS  Google Scholar 

  36. Hezard T, Fajerwerg K, Evrard D, Collière V, Behra P, Gros P (2012) J Electroanal Chem 664:46

    Article  CAS  Google Scholar 

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Acknowledgements

The authors are grateful for the financial support provided by the Ankara University Research Fund (project numbers FDK-2022-2501, 20L0430001, and 20B0430003).

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Authors and Affiliations

  1. Faculty of Science, Department of Chemistry, Ankara University, 06560, Ankara, Turkey

    Ümmüye Nur Tüzün, Ceren Yıldız, Dilek Eskiköy Bayraktepe, Kamran Polat & Zehra Yazan

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  1. Ümmüye Nur Tüzün
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  2. Ceren Yıldız
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Correspondence to Zehra Yazan.

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Tüzün, Ü.N., Yıldız, C., Eskiköy Bayraktepe, D. et al. Electrochemical fabrication of poly(l-alanine)-gold nanoparticle nanocomposite-modified electrode: application for determination and mechanism of antipsychotic drug olanzapine. Monatsh Chem 154, 95–104 (2023). https://doi.org/10.1007/s00706-022-03012-9

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