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Synthesis and antimicrobial activities of new thiosemicarbazones and thiazolidinones in indole series

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Abstract

New thiosemicarbazones were synthesized in excellent yield reaction of indole derivatives with thiosemicarbazides. These thiosemicarbazones were reacted with ethyl bromoacetate to produce original heterocyclic-substituted indole derivatives possessing a 4-oxo-thiazolidine group. Analytical IR and NMR spectra and elemental analysis were performed to reveal their structures. The antimicrobial activity of all synthesized compounds was evaluated for antibacterial activity in vitro against Gram-positive and Gram-negative bacteria. Antibacterial screening data showed that two compounds demonstrated activity against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. These preliminary results indicate that some of these newly synthesized compounds show a promising antibacterial potency.

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Acknowledgements

This work was supported by the CNRS (Centre National de la Recherche Scientifique) and Aix-Marseille University.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Exact Sciences, University of Mascara, Mascara, Algeria

    Abdelmadjid Benmohammed

  2. Laboratoire de Synthèse Organique Appliquée (LSOA), Département de Chimie, Faculté Des Sciences Exactes Et Appliquées, Université Oran1 Ahmed Ben Bella, BP 1524 El M’naouer, Oran, Algérie

    Abdelmadjid Benmohammed, Nawel Rekiba, Mokhtaria Kadiri & Ayada Djafri

  3. Unité de Microbiologie, Laboratoire Centrale, Hôpital Militaire Régional Universitaire D’Oran Dr Amir Mohamed Benaissa, B.P 35 Ahmed Medeghri, Oran, Algérie

    Nawel Rekiba, Yassine Sehanine & Ahmed Amine Louail

  4. Aix Marseille Université, CNRS, ICR Institut de Chimie Radicalaire, UMR 7273, Laboratoire de PharmacoChimie Radicalaire, Faculté de Pharmacie, 27 Boulevard Jean Moulin–CS 30064, 13385, Marseille Cedex 05, France

    Abdelmadjid Benmohammed, Omar Khoumeri, Thierry Terme & Patrice Vanelle

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  1. Abdelmadjid Benmohammed
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  2. Nawel Rekiba
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Correspondence to Abdelmadjid Benmohammed or Patrice Vanelle.

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Benmohammed, A., Rekiba, N., Sehanine, Y. et al. Synthesis and antimicrobial activities of new thiosemicarbazones and thiazolidinones in indole series. Monatsh Chem 152, 977–986 (2021). https://doi.org/10.1007/s00706-021-02823-6

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  • DOI: https://doi.org/10.1007/s00706-021-02823-6

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