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A convenient synthesis of 2-azetidinones via 2-fluoro-1-methylpyridinium p-toluenesulfonate

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Abstract

The application and versatility of 2-fluoro-1-methylpyridinium p-toluenesulfonate as acid activator in the synthesis of several β-lactams under mild reaction conditions by use of ketene–imine cycloaddition reactions has been investigated. The effects of solvents, molar ratio of reagents, and temperature were considered. The method was also used for preparation of β-lactams substituted in position 3 by electron-withdrawing groups. The products are obtained in good to excellent yields.

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Acknowledgments

The author is grateful to Hormozgan University Research Council for financial assistance.

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Authors and Affiliations

  1. Department of Chemistry, College of Sciences, Hormozgan University, 71961, Bandar Abbas, Iran

    Maaroof Zarei

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  1. Maaroof Zarei
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Correspondence to Maaroof Zarei.

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Zarei, M. A convenient synthesis of 2-azetidinones via 2-fluoro-1-methylpyridinium p-toluenesulfonate. Monatsh Chem 144, 1021–1025 (2013). https://doi.org/10.1007/s00706-012-0918-y

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  • DOI: https://doi.org/10.1007/s00706-012-0918-y

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