Summary
Feline immunodeficiency virus (FIV) is classified into five genotypes, A, B, C, D and E, based on the phylogenetic analysis of the env V3-V5 region. However, whether there is correlation between phylogenetic and antigenic diversities remains unknown. In this study, we examined the cross virus neutralization of FIV genotypes A through E by sera from cats infected with a single genotype. The results indicated some relationships between phylogenetic genotype and neutralization serotype, and that cross-clade virus neutralization is possible. For example, serum from a cat infected with genotype E virus neutralized all five FIV genotypes. Our results suggest that the FIV subtyping according to the sequence diversity is partially reflected by antigenic diversity and serum neutralization.
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Accepted September 23, 1997 Received August 7, 1997
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Inoshima, Y., Miyazawa, T., Kohmoto, M. et al. Cross virus neutralizing antibodies against feline immunodeficiency virus genotypes A, B, C, D and E. Arch. Virol. 143, 157–162 (1998). https://doi.org/10.1007/s007050050275
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DOI: https://doi.org/10.1007/s007050050275