Summary
We investigated the possibility of in vitro recombination of three different trains of feline herpesvirus type 1 (FHV-1), a virulent strain (C7805), a vaccine strain (F2), and a candidate vaccine strain with a deletion in the thymidine kinase gene (C7301dlTK). The results showed that recombination within different genotypes of FHV-1 strains could occur at a relatively high frequency ranging from 10.1% to 21.5% in vitro. These results indicate the generation of multiple mutant viruses by in vitro recombination experiments. The possibility for generating a virulent virus or novel type of FHV-1 by recombination in vivo is discussed.
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Accepted September 12, 1997 Received July 17, 1997
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Fujita, K., Maeda, K., Yokoyama, N. et al. In vitro recombination of feline herpesvirus type 1. Arch. Virol. 143, 25–34 (1998). https://doi.org/10.1007/s007050050265
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DOI: https://doi.org/10.1007/s007050050265