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Translating the language of giants: translation-related genes as a major contribution of giant viruses to the virosphere

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Abstract

Giant viruses of amoebas are a remarkable group of viruses. In addition to their large size and peculiar structures, the genetic content of these viruses is also special. Among the genetic features of these viruses that stand out is the presence of coding regions for elements involved in translation, a complex biological process that occurs in cellular organisms. No viral genome described so far has such a complex genetic arsenal as those of giant viruses, which code for several of these elements. Currently, tupanviruses have the most complete set of translation genes in the known virosphere. In this review, we have condensed what is currently known about translation genes in different groups of giant viruses and theorize about their biological importance, origin, and evolution, and what might possibly be found in the coming years.

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Acknowledgements

We thank colleagues from Universidade Federal de Minas Gerais for technical assistance and discussions. We also thank CAPES, CNPq and FAPEMIG for scholarships and grants. JSA is a CNPq researcher. The authors declare no conflict of interest.

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  1. Department of Microbiology, Federal University of Minas Gerais, Belo Horizonte, Brazil

    Rodrigo Araújo Lima Rodrigues, Lorena Christine Ferreira da Silva & Jônatas Santos Abrahão

  2. Department of Biological Sciences, Federal University of Ouro Preto, Ouro Preto, Brazil

    Rodrigo Araújo Lima Rodrigues

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Rodrigues, R.A.L., da Silva, L.C.F. & Abrahão, J.S. Translating the language of giants: translation-related genes as a major contribution of giant viruses to the virosphere. Arch Virol 165, 1267–1278 (2020). https://doi.org/10.1007/s00705-020-04626-2

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